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Scientists engineer CRISPR enzymes that evade immune system

The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate unwanted immune responses in people, increasing the chances of side effects and making these therapies ...

Mammalian outer ear traced back to ancient fish gills

The outer ear is unique to mammals, but its evolutionary origin has remained a mystery. According to a study published in Nature from the USC Stem Cell lab of Gage Crump, this intricate coil of cartilage has a surprisingly ...

The Balbiani body: Cracking the secret of embryonic beginnings

Researchers have uncovered how egg cells prepare for the creation of life. Their work reveals the secrets of the Balbiani body (Bb), a remarkable structure that organizes essential molecules to guide early embryonic development.

'Killer' fungal gene could provide key to control of plant diseases

A critical gene that leads to the synthesis of a protein known as Knr4 could be the key to what makes some fungal pathogens so virulent. Focusing prevention strategies on disabling or modifying this gene or the protein it ...

How macronucleophagy ensures survival in nitrogen-starved yeast

Autophagy, the cell's essential housekeeping process, involves degrading and recycling damaged organelles, proteins, and other components to prevent clutter. This vital mechanism, found in all life forms from single-celled ...

Uncovering clues to a natural gene-editing technique

Diversity-generating retroelements (DGRs) are found in the genomes of microorganisms across the globe—from the arctic permafrost to Yellowstone's hot springs and the human gut. DGRs are able to reverse-transcribe RNA back ...

Scientists create scalable solution for analyzing single-cell data

Researchers have amassed vast single-cell gene expression databases to understand how the smallest details impact human biology. However, current analysis methods struggle with the large volume of data and, as a result, produce ...

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Biotechnology
A new era in genetic engineering: Researchers present single tool with multiple gene editing functions
Cell & Microbiology
Computational biologists develop AI that predicts inner workings of cells
Biotechnology
Optical tweezer technique reveals novel disease indicators in aging animals
Plants & Animals
New orchid found on Australian island resembles a cupcake
Molecular & Computational biology
Findings may help researchers develop a medication-friendly grapefruit
Ecology
Snail darter revisited: Famous fish that halted a dam's construction is not endangered after all
Evolution
Study finds two classes of plant enzymes that ignore common rule of evolution
Other
Reexamining the Prisoner's Dilemma: Study finds diversity and context play a larger role than thought
Plants & Animals
Why the scarlet velvet ant's sting is so painful to so many different species
Cell & Microbiology
Lock and key: Scientists clarify how important proteins 'dock' to centromere
Cell & Microbiology
Signaling circuit interplay pushes newborn neurons out of the neuronal nest
Cell & Microbiology
Unlocking cell recycling: Weak molecular interactions provide new possibilities for artificial control
Cell & Microbiology
How electrical synapses fine-tune sensory information for better decisions
Biotechnology
Low-symmetry coordination cages enable sensitive recognition and selective enrichment of higher fullerene isomers
Cell & Microbiology
Newly discovered mechanism triggers immune response in cells with damaged DNA
Ecology
A new way to determine whether a species will successfully invade an ecosystem, including the human GI tract
Biotechnology
Framework tracks 'learning curve' of AI to decode complex genomic data
Cell & Microbiology
Membrane anchor suppresses protein aggregation in neurodegenerative diseases, modeling study shows
Biotechnology
Microbes can colonize space, produce drugs and create energy. But how?
Cell & Microbiology
Taking a step back from the cell membrane debate: Simplified models offer fresh perspective

Other news

Nanophysics
Domain wall fluctuations in 2D materials reveal a new mechanism of superconductivity
Planetary Sciences
Water and carbon dioxide detected in the atmosphere of a hot super-Neptune exoplanet
Archaeology
Neolithic Italian skull cache suggests centuries of ancestor veneration rituals
Ecology
New research refutes notion that prehistoric kangaroos ran out of food due to specialized diets
Astronomy
Discovery poised to help detect dark matter and pave way to unravel the universe's secrets
Planetary Sciences
AI categorizes 700 million aurora images for better geomagnetic storm forecasting
Social Sciences
Trust paradox: Benefiting from betrayal doesn't always erode trust
Cell & Microbiology
Discovery of new skeletal tissue advances regenerative medicine potential
Earth Sciences
Rewriting the equation for deformation and flow of watery glacier ice
Environment
Arsenic's atmospheric journey: New methods reveal environmental toxin's transport pathways
Space Exploration
Spacecraft buzzes Mercury's north pole and beams back stunning photos
Cell & Microbiology
AI-powered staining in microbiology: Researchers introduce virtual Gram staining of label-free bacteria
Evolution
How ancient flying reptiles ruled the skies: Study uncovers pterosaur tail structures that enhanced flight capabilities
Polymers
Single-step coating offers scalable, non-toxic flame protection for fabrics
Plants & Animals
Logging and conversion of tropical forests to oil palm plantations have wide effects on ecosystems, study shows
Analytical Chemistry
Wireless electrochemical synthesis: Microelectronics transform well plate for high-throughput experimentation
Planetary Sciences
Samples from Mars' surface could unravel planet's history, researchers argue
Environment
Social and economic disparities impact wildfire protection in California
Astronomy
High-resolution simulations explore the physics of star formation
Bio & Medicine
Inhalable therapy uses mussel-inspired nanoparticles to target lung cancer cells

CRISPR screening method uses colored nuclei to reveal key genes

The identification of genes involved in diseases is one of the major challenges of biomedical research. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have developed a method that makes their ...

New method maps hundreds of proteins in cell nuclei simultaneously

Caltech researchers have developed a new method to map the positions of hundreds of DNA-associated proteins within cell nuclei all at the same time. The method, called ChIP–DIP (Chromatin ImmunoPrecipitation Done In Parallel), ...

Q&A: AI in the life sciences—why models often fail in practice

Artificial intelligence (AI) based on machine learning offers opportunities for the life sciences. However, problems often arise in practice. One cause is data leakage, the illicit spillover of information from the training ...