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Screen reveals new proteins that control RNA processing

Researchers at the University of California San Diego have developed a large-scale screening approach that identifies proteins controlling a fundamental step in gene expression known as alternative polyadenylation (APA). ...

Secrets of how we see color revealed at the molecular level

A global team has cracked a decades-old mystery, revealing the atomic structures of the molecules in our eyes that allow us to see colors. "To understand how we detect light and perceive colors, we need to know the exact ...

Ultra-precise technology can count damaged DNA fragments

The Korea Research Institute of Standards and Science has developed an ultrasensitive immunoassay-based analytical platform that can detect and quantify trace amounts of "Small Excised Damaged DNA (sedDNA)" fragments generated ...

Four-decade mystery solved as PKCβ structure reveals new drug target

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structure of protein kinase C beta (PKCβ), a key protein linked to cancer and neurological diseases. The findings, published in Nature ...

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Cell & Microbiology
Completing DNA replication triggers genomic instability in bacteria
Cell & Microbiology
Chloroplast study reveals molecular lock that helps power life on Earth
Cell & Microbiology
Discovery of how cells maintain their DNA could shield key healthy cells from chemotherapy side effects
Plants & Animals
Plant protein pair reveals new wood-formation mechanism
Cell & Microbiology
DNA loops reveal how immune cells build millions of antibodies from one genome
Ecology
Honeybee metamorphosis map uncovers 842 active DNA switches that drive worker bee development
Evolution
Zebrafish and fruit flies share the same internal compass mechanism in a case of convergent evolution
Cell & Microbiology
Real-time imaging reveals 'RNA hub' driving adaptive immune response
Evolution
How thousands of nature's longest sperm squeeze into a tiny fruit fly
Molecular & Computational biology
Cats age like humans—could studying their brains reveal healthy aging secrets?
Ecology
Mosquito-borne viruses avoid killing hosts by limiting protein output, study reveals
Cell & Microbiology
Cryo-EM imaging reveals how a molecular gate lets bulky proteins pass cell membranes intact
Biotechnology
Protein-tagging technology maps a hidden communication network between organs
Biotechnology
CRISPR safety check evaluates intended and unintended mutations
Cell & Microbiology
Ordinary enzyme that evolves into 'control switch' reveals tuberculosis weak spot
Ecology
Researchers reveal Hong Kong as a 'biodiversity ark' for yellow-crested cockatoos and expand nesting support
Molecular & Computational biology
Mapping cotton bacterial blight resistance
Molecular & Computational biology
Researchers develop antiviral candidate for deadly mosquito-borne brain infections
Cell & Microbiology
MINDY3: A hub between protein quality control and DNA repair
Evolution
Jumping gene caught moving between species in first direct observation

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Evolution
Primate evolution kept aging rates stable for 25 million years despite lifespan gaps
General Physics
World's largest particle smasher halts for upgrade to boost hunt for dark matter
Astronomy
New millisecond pulsar discovered with the Murchison Widefield Array
Plants & Animals
The bond between humans and dogs remains remarkably consistent across societies, cross-cultural study reveals
Earth Sciences
Coastal and estuarine carbon removal technique may backfire when pushed too far
Cell & Microbiology
Peptide alternative to antibiotics could combat antimicrobial resistance crisis
Evolution
Newly identified fossil sheds light on evolutionary history of saber-toothed cats
Environment
Burned-home soils showed uneven lead, arsenic contamination after Los Angeles wildfires
General Physics
Non-Hermitian geometry reveals when quantum amplification depends only on start and end points
Evolution
Lamprey brain atlas reveals 450-million-year blueprint of vertebrate brains
Other
Saturday Citations: Predicting earthquakes; two types of water; observing event horizons
Biochemistry
New workflow transforms nonfunctional protein scaffolds into active enzymes
Planetary Sciences
A large, harmless asteroid will zip past Earth this weekend
Plants & Animals
Two humpback whales set records swimming between Australia and Brazil
Astronomy
May 2024 superstorm drew most ring current ions from Earth, not solar wind, research reveals
General Physics
Metal hydride molecule trapped with laser light opens path to ultracold hydrogen
Earth Sciences
Coal pollution reaches one of Earth's most remote mountain regions
Ecology
An iron-driven chain reaction may trigger mass death of harmful algae blooms
Astronomy
A single origin story for the Milky Way's most mysterious stars
Astronomy
Ultraluminous X-ray source in Whale galaxy investigated for spectral and timing variability

How Argonaute, a key protein for RNA therapeutics, becomes activated

RNA therapeutics have emerged as one of the most promising new classes of medicines. Eight small interfering RNA (siRNA) drugs have already been approved worldwide for the treatment of genetic diseases, yet scientists have ...

Scientists uncover RNA's hidden role as protein chaperone

Proteins are how cells get work done. They carry out nearly every important cellular task, from ferrying messages to controlling which genes are turned on or off. And in order for proteins to perform their various roles, ...

Farmed oysters may boost New York's dwindling wild populations

Farmed oysters are mixing with and potentially adding to populations of wild oysters—a once-abundant species in New York's estuaries and rivers that has declined drastically over the last century. A new study, published in ...

Why are sloths slow? It's in their DNA

Sloths are the slowest mammals on the planet, but living in dense jungles has made them notoriously difficult to study. For the first time, scientists have now sequenced and analyzed the two-toed sloth genome and revealed ...