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Molecular & Computational biology news
AI-designed proteins built from scratch can recognize specific compounds
Professor Gyu Rie Lee of the Department of Biological Sciences successfully designed artificial proteins that selectively recognize specific compounds using AI through joint research with Professor David Baker. The research, ...
Biotechnology
15 minutes ago
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Turning uncertainty into a design tool for AI-engineered molecules
While precision seems critical for science, researchers from the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and Texas A&M University are embracing uncertainty, using it to fine-tune artificial intelligence ...
Molecular & Computational biology
1 hour ago
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AI diffusion models tailor drug molecules to custom-fit protein targets, speeding drug development and evaluation
University of Virginia School of Medicine scientists have developed a bold new approach to drug development and discovery that could dramatically accelerate the creation of new medicines. UVA's Nikolay V. Dokholyan, Ph.D., ...
Biotechnology
2 hours ago
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Liquid-like histone H1 'glues' nucleosomes, reshaping how DNA compacts
DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a dynamic, fluid organization that can still support essential genome functions.
Cell & Microbiology
3 hours ago
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A smarter way to build vaccines: Scientists harness AI to target emerging alphaviruses
A team of scientists at The University of Texas Medical Branch (UTMB), led by Nikos Vasilakis, Ph.D., and Peter McCaffrey, MD, has developed a new computational pipeline that could dramatically accelerate the development ...
Molecular & Computational biology
4 hours ago
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This giant virus just gave up its atomic blueprint
A research group has successfully determined, for the first time in the world, the capsid (outer shell) structure of Melbournevirus—a member of the giant virus family—at a resolution of 4.4 Å using cryo-electron microscopy ...
Cell & Microbiology
5 hours ago
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Keeping up with the phages: How V. cholerae neighbors swap defenses against viruses
Like most bacteria, Vibrio cholerae lives under constant attack from viruses. To survive, bacteria equip themselves with antiviral immune systems. Previous work has shown that V. cholerae carries a large genetic element called ...
Cell & Microbiology
5 hours ago
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Oxygen sensing helps explain why amphibians regenerate limbs but mammals cannot
Some animals can regrow lost body parts. Salamanders and frog tadpoles can rebuild entire limbs after amputation. Mammals cannot. For decades, biologists have tried to understand why. Now a team led by Can Aztekin at EPFL ...
Plants & Animals
5 hours ago
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Dragonflies share humans' red-light sensing trick, detecting wavelengths near 720 nm
Sometimes, different organisms can evolve the same ability independently, a process called parallel evolution. A new study from Osaka Metropolitan University (OMU) has found that dragonflies sense red light similarly to mammals, ...
Evolution
9 hours ago
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One DNA letter can trigger complete sex reversal
Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development in mice. In the new study, published in Nature Communications, a single-letter insertion in a non-coding ...
Molecular & Computational biology
14 hours ago
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Mathematical model predicts fish freshness in real time
Every day, fish caught in oceans and seas around the world pass through a long journey before reaching supermarkets, restaurants, and home kitchens. Along the way, their freshness steadily declines, often in ways that are ...
Molecular & Computational biology
Apr 8, 2026
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The binding sites that guide fungal 'vesicle hitchhiking'—new study maps mRNA transport
A specific protein controls mRNA transport in fungi and distinguishes important from unimportant binding sites in the transported mRNAs. Researchers from Würzburg and Düsseldorf have discovered this mechanism.
Cell & Microbiology
Apr 8, 2026
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Glucose transport may hinge on a fleeting transition-like state
Stockholm University and SciLifeLab researchers have uncovered how glucose transporters move nutrients into cells, bridging a long-standing gap between structure and function in membrane biology. "Our study shows that these ...
Cell & Microbiology
Apr 8, 2026
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AI uncovers hidden immune defenses inside bacteria
Researchers at the Massachusetts Institute of Technology (MIT) have discovered thousands of new proteins that protect bacteria from virus attacks using an AI system called DefensePredictor. What would usually take months ...
Split shift: A surprising twist in the biology of aging
A new Yale study of flatworms, a species with the unique ability to regenerate, reveals that disruptions in the body's internal map of cellular organization may play a part in age-related decline.
Cell & Microbiology
Apr 8, 2026
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Climate change may speed evolution through inherited gene regulation changes
A new paper in Molecular Biology and Evolution, finds that changes in animal development induced by climate shock persist generations after the initial event. The escalating effects of climate change are likely to, in effect, ...
Evolution
Apr 8, 2026
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AI is reengineering drug discovery by speeding up testing and scanning petabytes of data
In December, The Conversation hosted a webinar on AI's revolutionary role in drug discovery and development. Science and technology editor Eric Smalley interviewed Jeffrey Skolnick, eminent scholar in computational systems ...
Molecular & Computational biology
Apr 7, 2026
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This protein helps cancer cells survive treatment—and points to new treatments
Researchers at Umeå University have contributed new insights into how cancer cells protect themselves from cell death. The study provides a deeper understanding of how key proteins interact within the cell and could, in the ...
Cell & Microbiology
Apr 7, 2026
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Molecular 'leash' measures force-sensing protein activation at about 15 piconewtons
Researchers at the National University of Singapore (NUS) have built a molecular "leash" to pull directly on a force-sensing protein called Piezo1, and discovered it switches on at about 15 piconewtons, proving that it can ...
Biotechnology
Apr 7, 2026
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Researchers clarify how cells remove damaged endoplasmic reticulum
The cell's endoplasmic reticulum (ER) plays a central role in protein synthesis, folding, and calcium (Ca²⁺) storage. When damaged, ER-phagy (self-eating) removes affected ER regions via double-membrane vesicles called autophagosomes. ...
Cell & Microbiology
Apr 7, 2026
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Scientists study radiation limits for safer seafood shipping
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One of cholera's great enemies is found in the human gut
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What if dark matter came in two states?
Ant larvae control parental care by using odor signals
Examining embryo model ethics beyond box-checking
