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New enzyme atlas rewrites decades of biology research

WEHI researchers have led a major global effort to create the first authoritative atlas for a class of enzymes that regulate almost every cellular process in the human body. Published in Cell, the study establishes the first ...

Bacteria invent another way to turn on genes

In their landmark 1961 paper on the lac operon, Nobel laureates François Jacob and Jacques Monod speculated that RNA might control gene activity in bacteria through base-pairing interactions. But once protein transcription ...

New technique reveals body-wide cellular processes

Understanding gene expression within the body has been a boon for 21st century biology and therapeutics, but most discoveries that use these technologies only focus on one organ or one small area of tissue. At the University ...

Understanding protein motion could greatly aid new drug design

For many people, "protein" is the key element of a food order. However, beyond the preferred choice of meats or plant-based alternatives, proteins encompass a large class of complex biomolecules whose chemical structure is ...

Designing proteins by their motion, not just their shape

Proteins are far more than nutrients we track on a food label. Present in every cell of our bodies, they work like nature's molecular machines. They walk, stretch, bend, and flex to do their jobs, pumping blood, fighting ...

DNA shape explains crucial gene-therapy challenges

CRISPR is a powerful DNA-editing tool that has underpinned huge advancements in human health care in the last decade. It is a precision tool, but is not perfect, and misplaced DNA edits can compromise safety and efficacy, ...

Why cells respond 'incorrectly' in old age

Some of the signs of aging in human cells originate in the cell nucleus, because the packaged form of DNA changes with age. This has now been demonstrated by PSI researchers. It means that older cells can no longer react ...

Hearing research traces evolution of key inner ear protein

In the intricate machinery of the inner ear, hearing begins with a protein that moves a few billionths of a meter up to 100,000 times per second. That protein, called TMC1, sits at the tips of sensory hair cells deep in the ...

RNA-guided CRISPR system activates gene expression

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR gene-editing ...

How the body senses cold has been a mystery—until now

When you reach into a bucket of ice, open your front door on a snowy day, or feel the tingle of menthol toothpaste, a protein in your nerve cells called TRPM8 springs into action, opening like a tiny gate to send a "cold" ...

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Evolution
Uncovering the evolutionary limits of the COVID-19 virus
Evolution
The earliest dogs in Europe: 14,200-year-old DNA helps reveal their identity
Cell & Microbiology
Genomes reveal five E. coli 'armor' types behind most multidrug-resistant bloodstream infections
Plants & Animals
Eight amino acids may explain salamanders' reduced cold sensitivity
Cell & Microbiology
The hidden cost of sperm storage: Ejaculates found to deteriorate across the animal kingdom
Plants & Animals
Mammal cloning cannot be endless: Mouse line fails at generation 58
Biotechnology
Single-cell imaging and machine learning reveal hidden coordination in algae's response to light stress
Ecology
Highly and casually active citizen scientists contribute equally valuable data
Cell & Microbiology
Alternative pathways in proteasome biogenesis deciphered
Cell & Microbiology
The truth of timekeeping lies within: Key developments in understanding circadian rhythms
Molecular & Computational biology
Discovery of genetic switch could help turn rice into a perennial crop
Molecular & Computational biology
Why cultivating drought-resistant plants disappoints: Soil physics may be the real bottleneck
Cell & Microbiology
New findings on the first steps in protein synthesis
Plants & Animals
Unlocking longevity insights from ancient bristlecone pine
Cell & Microbiology
Study reshapes understanding of interaction between organelles in animal cells
Cell & Microbiology
One step closer to deciphering TOR, the molecular machinery that makes humans and yeast grow
Evolution
Genome-hopping 'Starships' may explain why some pest-killing fungi stop working
Cell & Microbiology
Mining a methane-degrading bioreactor for protein rubies
Ecology
Researchers reveal m6A epigenetic modification controls arbovirus infection and transmission
Cell & Microbiology
Single-cell sequencing reveals unexpected protist diversity

Other news

General Physics
Human brain operates near, but not at, the critical point
Archaeology
Scandinavia's largest 'burial mound' may be a monument to catastrophe, not a king
General Physics
Lab-based mini-atmosphere reveals how turbulence changes on different scales
Analytical Chemistry
AI-driven framework uncovers new carbon structures—one thought to be harder than diamond
Evolution
Ancient DNA reveals earliest known dogs lived alongside Ice Age humans
Earth Sciences
North Sea wind farms may be reshaping sediment flows by 1.5 million tons a year
Archaeology
Ancient DNA finds 15,800-year-old dogs in Anatolia, buried like humans
Biochemistry
Supercomputer simulations map spliceosome motions in a two-million-atom human cell model
Soft Matter
Liquids can fracture like solids—researchers discover the breaking point
Earth Sciences
Study explains Antarctic sea ice growth and sudden decline
Earth Sciences
Alaska analysis shows continued loss of Arctic landfast sea ice
Space Exploration
Artemis II astronauts arrive at Florida launch site for first moon trip in 53 years
Other
Saturday Citations: Birthday cetaceans; quantifying children's play experiences; placebos still effective
Astronomy
JWST solves decades-long mystery about why Saturn appears to change its spin
Earth Sciences
Major volcanic eruptions might be driven by gas dissolving back into magma
Archaeology
Scientists testing new scanning technology discover mysterious structure beneath an ancient Egyptian city
Earth Sciences
Japan's giant caldera volcano is refilling 7,300 years later
Plants & Animals
How lifetime stress drives abnormal behaviors in lab monkeys
Cell & Microbiology
Implantable 'living pharmacy' produces multiple drugs inside the body
General Physics
Piezoelectric materials enable a new approach to searching for axions