Protecting ribosome genes to prevent aging

Aging is a process of gradual deterioration from exposure to time and the elements; this process begins with deterioration deep inside every cell. Researchers from Stanford University and the VA Palo Alto Health Care System ...

Structural biology: Until the last cut

Ribosomes are the cell's protein factories. Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich have now structurally characterized late stages in the assembly of the human small ribosomal subunit, yielding detailed ...

Mechanical force controls the speed of protein synthesis

As cells create proteins, the proteins modulate synthesis speed by exerting a mechanical force on the molecular machine that makes them, according to a team of scientists who used a combination of computational and experimental ...

On building ribossomes

Ribosomes are organelles responsible for protein synthesis in all living organisms. Ribosomes are made of proteins and RNA (Ribosomal RNA, rRNA) and putting the several elements in the right location requires a precise multi-step ...

Looking beyond genes to explain blood cells' fates

Scientists often talk about cell fate and commitment in terms of mechanisms that control gene expression (transcription factors, chromatin remodeling, etc.). But by studying Diamond-Blackfan anemia (DBA), rare genetic blood ...

Building the machinery that makes proteins

All of the proteins necessary for life are made by giant molecular machines called ribosomes. A ribosome, in turn, is built from proteins and ribosomal RNAs stitched together with immaculate precision.

Secrets of a little-known cancer ally revealed

Human cancers often have a little recognized ally— the increased size and number of a cell's organelles called the nucleolus. The nucleolus is where ribosomes, the cellular protein factories, are made. Ribosomes can also ...

Ribosomes found to induce somatic cell pluripotency

In 2012, a Japanese research group discovered that human skin cells acquire pluripotency when introduced to lactic acid bacteria (Lactobacillus acidophilus). Now, the same group of researchers has found that the cause of ...

Scientists discover a molecular timer based on stalling ribosomes

A molecular biologist from Lomonosov Moscow State University and international colleagues discovered a special mechanism of protein synthesis regulation that they called a "molecular timer." It controls the number of protein ...

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