CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital have used a next-generation protein degradation technology to study ...
Biotechnology
Jan 25, 2023
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22
The study of microRNAs (miRNAs), small RNAs that play important roles in gene regulation in animals and humans alike, have long been a topic of research interest. How these miRNAs control and regulate gene expression is believed ...
Molecular & Computational biology
Jan 20, 2023
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12
MicroRNAs (miRNA) are small non-coding RNAs that regulate almost all biological processes, protein production, inflammatory responses, immune regulation, tumorigenesis and infection. In mammals, the classic formation of miRNA ...
Cell & Microbiology
Jan 17, 2023
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9
Inside cells, proteins constantly interact with each other to carry out different functions. For some diseases in which these functions are altered, blocking the binding between two or more proteins emerges as a possible ...
Biotechnology
Nov 30, 2022
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18
Professor Hiroki Ueda, Assistant Professor Daisuke Tone, Lecturer Koji Ode, and Qianhui Zhang (4th-year graduate student at the time) at the University of Tokyo showed that CaMKIIβ, a predominant protein kinase expressed ...
Molecular & Computational biology
Oct 26, 2022
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7
For four decades, Specificity Protein 1 (Sp1) has been cast solely as a transcription factor, a type of protein that binds DNA and turns genes on. But a Donnelly Center study has now revealed that Sp1 plays another unexpected ...
Cell & Microbiology
Sep 6, 2022
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34
Chemotherapy sucks. The treatments generally have awful side effects, and it's no secret that the drugs involved are often toxic to the patient as well as their cancer. The idea is that, since cancers grow so quickly, chemotherapy ...
Biochemistry
Aug 24, 2022
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119
In almost every human cell, 2 meters of DNA has to fit within a nucleus that is just 8 millionths of a meter wide. Like wool around a spool, the extreme space challenge requires DNA to wrap around structural proteins called ...
Evolution
Jun 9, 2022
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47
How is the activity of genes regulated by the packaging of DNA? To answer this question, a technique to measure both gene expression and DNA packaging at the same time was developed by Franka Rang and Kim de Luca, researchers ...
Cell & Microbiology
Apr 1, 2022
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134
In an article in the Science, researchers at Uppsala University show how a DNA-binding protein can search the entire genome for its target sequence without getting held up on the way. The result contradicts our current understanding ...
Molecular & Computational biology
Jan 27, 2022
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