For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require ...
Biochemistry
Dec 28, 2023
0
203
The walnut (Juglans regia L.), which was domesticated in ancient Persia, is a globally cultivated nut crop. With global water scarcity, walnut production is facing significant challenges due to abiotic stresses, especially ...
Molecular & Computational biology
Dec 21, 2023
0
16
Exploring the biomedical interactions for chemical compounds and protein targets is crucial for drug discovery. Determining these drug–drug interactions (DDI) and drug–target interactions (DTI) not only reveals the potential ...
Molecular & Computational biology
Dec 5, 2023
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23
Researchers at Kanazawa University report in the Journal of Physical Chemistry Letters high-speed atomic force microscopy studies that shed light on the possible role of the open reading frame 6 (ORF6) protein in COVID-19 ...
Biochemistry
Nov 29, 2023
0
59
Jianwei Shuai's team and Jiahuai Han's team at Xiamen University have developed a deep autoencoder-based data-independent acquisition data analysis software for protein mass spectrometry, which realizes the analysis of relevant ...
Analytical Chemistry
Nov 3, 2023
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5
Biological markers, commonly referred to markers or biomarkers, serve as quantifiable and measurable indicators of certain biological states in normal and pathogenic processes, as well as potential pharmacologic responses ...
Plants & Animals
Nov 2, 2023
0
23
A detailed atomic exploration into how the dengue virus replicates its genome could catalyze the development of high-precision targeted antiviral therapeutics.
Cell & Microbiology
Oct 31, 2023
0
1
Controlling the process of destabilization is important when manipulating the unfolding and refolding of proteins in vitro (outside their native environment). To this end, urea and alcohol are used as cosolvents, substances ...
Cell & Microbiology
Oct 19, 2023
0
33
Through a nuanced balance of electrical and hydrophobic forces, biological molecules self-assemble into the large functional structures that maintain life's vital functions. Understanding how proteins self-assemble requires ...
Cell & Microbiology
Sep 1, 2023
0
10
The key to understanding proteins—such as those that govern cancer, COVID-19, and other diseases—is quite simple: Identify their chemical structure and find which other proteins can bind to them. But there's a catch.
Biotechnology
Aug 3, 2023
0
77
