Natural selection results in protein sequences that are only soluble to the level that is required to carry out its physiological function. However, in biotechnological applications, we need these proteins to survive concentrations ...
Cell & Microbiology
Feb 29, 2016
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7
Cellular repair systems can dissolve aggregated proteins and now Heidelberg researchers have successfully decoded the fundamental mechanism that is key to dissolving these protein aggregates in human cells. Their in-vitro ...
Cell & Microbiology
Aug 12, 2015
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99
Diseases like Alzheimer's are caused when proteins aggregate and clump together. In a world first, EPFL scientists have successfully distinguished between the disease-causing aggregation forms of proteins. The finding can ...
Biochemistry
Jul 28, 2015
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16
Working towards the ultimate goal to develop therapeutics to treat diseases such as Alzheimer's, Parkinson's, ALS, and BSE (Mad Cow Disease), University of Alberta scientists Michael Woodside, Hao Yu, and Derek Dee are investigating ...
Cell & Microbiology
Jun 25, 2015
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16
Researchers from FOM Institute AMOLF have, for the first time ever, managed to make an image of the exterior structure of a protein aggregate that causes diseases like Alzheimer and type-2 diabetes. They discovered that the ...
Bio & Medicine
May 8, 2015
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615
As an organism ages, a gradual loss of cellular protein quality control occurs. This results in the increased production of toxic protein clumps, so-called aggregates. Using a comprehensive approach, researchers in the teams ...
Cell & Microbiology
May 8, 2015
0
43
Researchers have developed a new computational method called AGGRESCAN3D which will allow studying the 3D structure of folded globular proteins and substantially improve the prediction of any propensity for forming toxic ...
Cell & Microbiology
Apr 27, 2015
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15
Free-standing nanoparticle films are of great interest for technical applications, such as the development of nanoelectronic devices. In the journal Angewandte Chemie, Korean scientists have introduced very flexible and stable ...
Nanomaterials
Feb 19, 2015
1
41
We all pass unwanted stuff on to our children—emotional baggage, peculiar habits, unfashionable furniture. Cells do the same thing when they divide; along with their newly replicated genomes and the vital cellular organelles, ...
Cell & Microbiology
Jul 2, 2014
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0
A method by Rice University researchers to model the way proteins fold – and sometimes misfold – has revealed branching behavior that may have implications for Alzheimer's and other aggregation diseases.
Cell & Microbiology
Nov 25, 2013
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