A team of researchers at the University of Utah has found that nucleosomes can inhibit CRISPR/Cas9 cleavage efficiency. In their paper published in Proceedings of the National Academy of Sciences, the group describes testing ...
In the cell nucleus, the genomic DNA is packaged into a tightly condensed form, which is referred to as chromatin. The basic unit of chromatin organization is the nucleosome, a DNA-protein complex consisting of a defined ...
Cell & Microbiology
Sep 4, 2018
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11
In eukaryotic cells, linear genetic DNA wraps around histones to form stable nucleosomes that further assemble to form chromatins. Nucleosomes represent big barriers to the transcription machine RNA polymerase.
Cell & Microbiology
Jul 23, 2018
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11
A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. The method, ...
Cell & Microbiology
Jul 12, 2018
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128
A protein complex called facilitates chromatin transcription (FACT) plays a role in DNA packing within a nucleus, as well as in oncogenesis. A team of scientists from MSU, working in cooperation with foreign colleagues, have ...
Cell & Microbiology
May 28, 2018
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6
Until human genes are activated, they are blocked by structures known as nucleosomes, components that serve to package DNA inside cells.
Biotechnology
May 14, 2018
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144
DNA is tightly packed into the nucleus of a cell. Nevertheless, the cellular machinery needs to constantly access the genomic information. An LMU team now reveals the inner workings of a molecular motor made of proteins which ...
Cell & Microbiology
Apr 12, 2018
6
69
In cells, proteins tightly package the long thread of DNA into pearl necklace-like complexes known as chromatin. Scientists at EPFL show for the first time how chromatin moves, answering longstanding questions about how its ...
Cell & Microbiology
Jan 18, 2018
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21
Accessing DNA wrapped into basic units of packaging, called nucleosomes, depends on the underlying sequence of DNA building blocks, or base pairs. Like Christmas presents, some nucleosomes are easier to unwrap than others. ...
Biotechnology
Dec 5, 2017
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3
A fertilized human egg develops into multiple tissues, organs and about 200 distinct cell types. Each cell type has the same genes, but they are expressed differently during development and in mature cells.
Cell & Microbiology
Aug 30, 2017
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