PNP editing is emerging as a versatile and programmable tool for site-specific DNA manipulations. An innovative genome-editing technique could enhance the delivery, specificity and targeting of gene-modifying tools for treatments.
Biotechnology
Aug 24, 2023
1
196
Function and form are deeply intertwined in biology. Knowing how organisms grow, adapt and reproduce requires understanding their physical structures. Hence the transformative power of the microscope across the past four ...
Analytical Chemistry
Aug 4, 2023
0
20
In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept ...
Biotechnology
Jul 27, 2023
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69
Single-molecule DNA detection using nanopore technology offers real-time analysis of DNA and RNA strands. It is a low-cost and flexible technique that can be used in clinical and research settings when samples need to be ...
Biochemistry
Jul 26, 2023
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733
A newly described type of chemistry in fungi is both surprisingly common and likely to involve highly reactive enzymes, two traits that make the genes involved useful signposts pointing to a potential treasure trove of biological ...
Molecular & Computational biology
Jul 20, 2023
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916
Membraneless organelles (MLOs), also known as "biomolecular condensates," are formed by the biological process of liquid-liquid phase separation (LLPS). MLOs are highly dynamic bodies containing proteins and nucleic acids.
Cell & Microbiology
Jul 18, 2023
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12
In an advance that will help scientists track coronavirus variants in wild and domesticated animals, researchers report they can now detect exposure to the SARS-CoV-2 virus in any animal species. Most coronavirus antibody ...
Molecular & Computational biology
Jul 6, 2023
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3
In NMR spectroscopy, residual dipolar couplings (RDCs) have emerged as one of the most exquisite probes of biological structure and dynamics. The measurement of RDCs relies on the partial alignment of the molecule of interest ...
Biochemistry
Jul 3, 2023
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8
The human gut hosts a complex ecosystem comprising an intricate plasmidome with abundant undiscovered plasmids, driving horizontal gene transfer events.
Cell & Microbiology
Jun 28, 2023
0
27
Research led by the University of Pennsylvania, Philadelphia, has used siRNA-based silencing of protein cyclophilin A (CyPA) to reduce tumor burden and extend the lives of patients with multiple myeloma.
