Related topics: cancer cells

Ancient origins of allosteric activation in the oldest kinases

One of the key features in the evolution of more complex organisms is the emergence of allosteric regulation. Allostery is a process by which a protein's activity can be modulated by binding an effector molecule distal to ...

Mathematical model reveals behavior of cellular enzymes

Everything a cell does, from dividing in two to migrating to a different part of the body, is controlled by enzymes that chemically modify other proteins in the cell. Researchers at Princeton University have devised a new ...

Skin cancer mystery revealed in yin and yang protein

It starts off small, just a skin blemish. The most common moles stay just that way—harmless clusters of skin cells called melanocytes, which give us pigment. In rare cases, what begins as a mole can turn into melanoma, ...

Antibiotics: New substances break bacterial resistance

Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a promising new class of active ingredients against resistant bacteria. In initial tests in cell cultures and insects, the substances were ...

SciLifeLab and AstraZeneca use cryo-EM to advance biomedicine

A study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signalling complex, the study ...

SPEECHLESS, SCREAM and stomata development in plant leaves

Plants constantly make trade-offs in their decisions: more light means more opportunity for photosynthesis, but then hot temperatures and dry air makes wilting more likely. Stomata—microscopic valves on the surface of a ...

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