In the April 2018 issue of SLAS Discovery, a review article by Prof. Stefan Broer, Ph.D. of the Australian National University highlights opportunities and challenges in using amino acid transporters as drug targets. Amino ...
Biochemistry
Mar 21, 2018
0
7
McMaster University engineers have devised a way to make testing for new drugs more efficient and affordable, and reduce the time for helpful medications to reach the public.
Biochemistry
Feb 9, 2018
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7
MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive.
Biochemistry
Jan 16, 2018
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563
A joint industry/academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime. The results, published in Nature Communications, suggest a new strategy for drug ...
Biochemistry
Jan 15, 2018
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20
Most drugs work by tinkering with the behavior of proteins. Like meddlesome coworkers, these molecules are designed to latch onto their target proteins and keep them from doing what they need to do.
Biochemistry
Oct 11, 2017
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59
o-Succinylbenzoyl-CoA (OSB-CoA) synthetase (MenE) is an essential enzyme in bacterial vitamin K biosynthesis and an important target in the development of new antibiotics. It is a member of the adenylating enzymes (ANL) family, ...
Biochemistry
Sep 13, 2017
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3
When designing and characterizing new drugs, a key aspect is making sure the drug actually goes where it is intended to. But current tests for drug uptake monitor the process under unrealistic conditions and do not provide ...
Analytical Chemistry
Aug 2, 2017
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1
Scientists have developed a new technique for investigating the effects of gene deletion at later stages in the life cycle of a parasite that causes malaria in rodents, according to a new study in PLOS Pathogens. The novel ...
Cell & Microbiology
Jun 15, 2017
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107
A new technique that will allow scientists to determine the effects of turning on and off a set of molecules involved in almost every cellular pathway, determine their downstream effects, and uncover new drug targets has ...
Biochemistry
Dec 13, 2016
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395
Cancer researchers and drug companies may have been too quick to ignore a promising line of inquiry that targets a specific cell protein, according to a research team led by a biomedical scientist in the School of Medicine ...
Biochemistry
Dec 9, 2016
0
348
