In this week's issue of Science Signaling (22 January, 2013), Danen and colleagues of the Division of Toxicology of LACDR report novel insights into the question how stem cells decide to commit suicide when their DNA is damaged.
Cell & Microbiology
Jan 23, 2013
0
0
Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...
Biochemistry
Mar 1, 2012
0
0
DNA-damaging agents, or "DDAs," make up the most widely used group of cancer drugs. Yet their therapeutic success has been curtailed by drug resistance—either present in cancer cells from the disease onset or arising during ...
Molecular & Computational biology
Oct 29, 2018
0
48
In bacteria, toxin-antitoxin systems consist of a set of two closely linked genes. Situated on the same chromosome, they encode both a protein 'poison' and a counteracting 'antidote'. Under normal conditions, the antitoxin ...
Cell & Microbiology
Feb 22, 2016
0
6
Earlier work from the laboratory of Susan Gasser had noted changes in the physical behavior of chromatin when it incurred DNA damage: loci bearing double-strand breaks showed enhanced movement, becoming highly dynamic. Furthermore, ...
Cell & Microbiology
Jan 10, 2017
0
12
Research carried out at the Institute of Molecular Biology and Biotechnology (IMBB) of FORTH, provides evidence that persistent DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation ...
Cell & Microbiology
Nov 26, 2021
0
154
Investigators at Burnham Institute for Medical Research (Burnham) have deciphered a large percentage of the total protein complement (proteome) in Schizosaccharomyces pombe (S. pombe) fission yeast.
Cell & Microbiology
Apr 8, 2009
0
0
How does our body keep its DNA intact? Researchers at Erasmus MC have just found a new piece of this puzzle. They discovered a novel alarm that cells use to signal DNA damage. "We already knew that DNA damage triggers an ...
Cell & Microbiology
Jun 25, 2015
0
14
Our genomes encounter DNA damaging events continuously. As damage accumulates, our cells react and stop the cell division process, giving repair mechanisms time to act. To achieve this, two master protein kinases called ATR ...
Cell & Microbiology
Dec 19, 2014
0
0
Ishan Deshpande and his colleagues from the group of Susan Gasser and the Protein Structure Facility at the FMI elucidated the mechanism of how Mec1-Ddc2, a tumor suppressor involved in DNA damage response assembles at sites ...
Cell & Microbiology
Oct 16, 2017
0
68
