NUS researchers have identified post-translational modifying enzymes in bacteria that can create a new family of cyclic peptides for new therapeutics.
Biochemistry
Oct 15, 2020
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40
Cyclic peptides often exhibit low membrane permeability that can be significantly improved via amide-to-ester substitutions, as demonstrated by researchers from Tokyo Institute of Technology (Tokyo Tech). The utilization ...
Biochemistry
Mar 17, 2023
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65
The Australian stinging tree (Dendrocnide moroides) is a plant that many people avoid at all costs. The tree, which is a member of the nettle family, is covered in thin silicon needles laced with one of nature's most excruciating ...
Biochemistry
Apr 21, 2022
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106
Research teams from the National Institutes of Health and abroad have identified the first inhibitor of an enzyme long thought to be a potential drug target for fighting disease-causing parasites and bacteria. The teams, ...
Biochemistry
Apr 3, 2017
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27
Because biopharmaceuticals are medium- and high-molecular-weight, biologically active macromolecules, they are not easily absorbed by the small intestine, resulting in a bottleneck for oral administration. Now, researchers ...
Biochemistry
Sep 21, 2017
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5
There is a need for new drugs. For example, many of the antibiotics that we have been using for a long time are becoming less effective. Chemists and pharmaceutical scientists are frantically searching for new active substances, ...
Biochemistry
Apr 13, 2023
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38
Macrocyclic peptides are promising candidates for pharmaceuticals, but their screening is difficult. Scientists have now developed an easy-to-use, high-throughput screening assay for cyclic peptides with affinity to ubiquitin, ...
Biochemistry
Feb 22, 2021
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13
CycPeptMPDB, a novel database created by Tokyo Tech researchers, focuses on the membrane permeability of cyclic peptides and could accelerate the development of drugs based on these promising compounds. This database was ...
Biochemistry
Apr 5, 2023
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36
Many plants produce compounds that serve as a defense against predators or pathogens. Some are also used by humans for a variety of beneficial purposes, such as in medicines. As recently as the early 1990s, a unique class ...
Cell & Microbiology
Dec 12, 2011
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0
Tyrosinase is a multifunctional copper-containing enzyme widely distributed in microorganisms as well as plants and animals which has a primordial role in melanin biosynthesis thus impacting on skin color and pigmentation. ...
Biochemistry
Feb 18, 2016
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