News tagged with chromatin
Nuclear pores call on different assembly mechanisms at different cell cycle stages
Nuclear pores are the primary gatekeepers mediating communication between a cell's nucleus and its cytoplasm. Recently these large multiprotein transport channels have also been shown to play an essential ...
Jun 10, 2010 |
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Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
factors controlling when and in what tissues genes are expressed - of Wilms tumor reveals striking similarities to stem cells normally found in fetal kidneys. These findings by Massachusetts General Hospital (MGH) Cancer ...
Jun 03, 2010 |
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MeCP2 goes global -- redefining the function of the Rett syndrome protein
A paper published online today in Molecular Cell proposes that Methyl CpG binding protein 2 (MeCP2) impacts the entire genome in neurons, rather than acting as a regulator of specific genes. Mutations in MeCP2 cause the au ...
Medicine & Health / Diseases, Conditions, Syndromes
Feb 25, 2010 |
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Researchers show 'trigger' to stem cell differentiation
A gene which is essential for stem cells' capabilities to become any cell type has been identified by researchers at the Hebrew University of Jerusalem and the University of California, San Francisco.
Dec 10, 2009 |
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Geneticist reveals molecular view of key epigenetic regulator
In a paper published this week in the journal Proceedings of the National Academy of Sciences, Dr. Michael Kobor reported the structure and function of a key player in regulating chromatin in yeast and humans.
Dec 09, 2009 |
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Singapore scientists describe novel method for 3-D whole genome mapping research
In this week's Nature, Genome Institute of Singapore (GIS) scientists report a technological advance in the study of gene expression and regulation in the genome's three-dimensional folding and looping state through the de ...
Nov 04, 2009 |
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Aurora B answers an XIST-ential question
Early in development, mammalian female cells counteract their double dose of X chromosomes by coating one of them with a large RNA named XIST. The RNA binds to the same X chromosome from which it is transcribed ...
Aug 24, 2009 |
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Scientists uncover function of potential cancer-causing gene product
The Stowers Institute's Conaway Lab has uncovered a previously unknown function of a gene product called Amplified in Liver Cancer 1 (Alc1), which may play a role in the onset of cancer. The work was published yesterday by ...
Medicine & Health / Medical research
Aug 09, 2009 |
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UCSD Engineer Provides Insights to Decades-Old DNA Squabble
(PhysOrg.com) -- A group of nanoengineers, biologists and physicists have used innovative approaches to deduce the internal structure of chromatin, a key player in DNA regulation, to reconcile a longstanding ...
Jul 31, 2009 |
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BRIT1 allows DNA repair teams access to damaged sites
Like a mechanic popping the hood of a car to get at a faulty engine, a tumor-suppressing protein allows cellular repair mechanisms to pounce on damaged DNA by overcoming a barrier to DNA access.
Jun 19, 2009 |
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Good fences make good neighbors
Our genome is a patchwork of neighborhoods that couldn't be more different: Some areas are hustling and bustling with gene activity, while others are sparsely populated and in perpetual lock-down. Breaking ...
May 14, 2009 |
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SUMO protein guides chromatin remodeler to suppress genes
In an in vitro study, led by Grace Gill, PhD, Tufts University School of Medicine, researchers discovered how a protein called SUMO (Small Ubiquitin-related Modifier) guides an enzyme complex that alters the structure of ...
Medicine & Health / Medical research
Apr 27, 2009 |
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Protein complex shown to play pivotal role in stem cell development in 2 Stanford studies
Scientists at the Stanford University School of Medicine have identified a protein complex important in controlling whether embryonic stem cells retain their ability to become any cell in the body — a quality called pluripotency ...
Medicine & Health / Medical research
Mar 02, 2009 |
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