Key tethering protein found to transport cellular cholesterol

Despite its less-than-stellar reputation in the news, cholesterol is an essential molecule for living things. It serves as the building block for hormones and gives shape to the membranes that enclose cells and their internal ...

How scientists analyze cell membranes

Exchange of material and information at the level of individual cells requires transport and signaling at the level of the plasma membrane enclosing the cell. Studying mechanisms at such tiny dimensions presents researchers ...

X-rays help advance the battle against heart disease

(PhysOrg.com) -- Scientists from Imperial College London and Diamond Light Source have revealed the structure of a cholesterol-lowering-drug target. Published in the journal Nature, this finding could lead to much more effective ...

Characterized drugs show unexpected effects

When Alexander Flemming discovered a mold on a culture plate overgrown with bacteria in 1928, he did not expect to find one of the most widely used active substances: penicillin. Accidental discoveries and the identification ...

'Shark molecule' protects cholesterol enzyme from destruction

A team of scientists have shown in cell lines that a key cholesterol synthesis enzyme—squalene monooxygenase (SM) – is controlled by the levels of its target molecule, squalene. The findings, published in international ...

Atomic map reveals clues to how cholesterol is made

In spite of its dangerous reputation, cholesterol is in fact an essential component of human cells. Manufactured by the cells themselves, it serves to stiffen the cell's membrane, helping to shape the cell and protect it. ...

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