MIB2 enhances inflammation by degradation of CYLD

A team of researchers at Ehime University revealed that E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. This finding was published on Sept. 20 in the Journal of Biological Chemistry.

A simpler way to differentiate B cells and T cells

Our immune system is essential for our survival, as our bodies are constantly being exposed to bacteria, viruses, parasites, and other pathogens. Without an immune system, we would quickly lose the war against these pathogens ...

Regulating the rapidly developing fruit fly

From birth, it takes humans almost two decades to reach adulthood; for a fruit fly, it takes only about 10 days. During a fly embryo's initial stages of development, the insect looks different from minute to minute, and its ...

Regulating hematopoietic differentiation

Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms underlying this ...

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