Rockefeller University

A snooze button for the circadian clock

We may use the snooze button to fine-tune our sleep cycles, but our cells have a far more meticulous and refined system. Humans, and most other organisms, have 24-hour rhythms that are regulated by a precise molecular clock ...

Aug 14, 2008
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Leptin's long-distance call to the pancreas

Rube Goldberg—the cartoonist who devised complex machines for simple tasks—would have smiled at one of leptin's mechanisms for curbing insulin release. As Hinoi et al. show, the fat-derived hormone enlists ...

Dec 22, 2008
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Immune genes adapt to parasites

Thank parasites for making some of our immune proteins into the inflammatory defenders they are today, according to a population genetics study that will appear in the June 8 issue of the Journal of Experimental Medicine (onlin ...

May 25, 2009
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Aging cells unravel their DNA

Senescent cells, which are metabolically active but no longer capable of dividing, contribute to aging, and senescence is a key mechanism for preventing the spread of cancer cells. A study in The Journal of ...

Dec 16, 2013
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