Scientists reveal molecular secrets behind resveratrol's health benefits

Apr 29, 2014
Kendall Nettles, Ph.D., is an associate professor at The Scripps Research Institute, Florida campus. Credit: Photo courtesy of The Scripps Research Institute

Resveratrol has been much in the news as the component of grapes and red wine associated with reducing "bad cholesterol," heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now identified one of the molecular pathways that uses to achieve its beneficial action. They found that resveratrol controls the body's inflammatory response as a binding partner with the estrogen receptor without stimulating estrogenic cell proliferation, which is good news for its possible use as a model for drug design.

The study was recently published as an accepted manuscript in the online journal eLife, a publication supported by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust.

"Estrogen has on conditions like diabetes and obesity but may increase cancer risk," said Kendall Nettles, a TSRI associate professor who led the study. "What hasn't been well understood until now is that you can achieve those same beneficial effects with something like resveratrol."

The problem with resveratrol, Nettles said, is that it really doesn't work very efficiently in the body. "Now that we understand that we can do this through the estrogen receptor, there might compounds other than resveratrol out there that can do the same thing—only better," he said.

"Our findings should lead scientists to reconsider the estrogen receptor as a main target of resveratrol—and any analogues," said Jerome C. Nwachukwu, the first author of the study and a research associates in the Nettles laboratory. "It has gotten swept under the rug."

In the new study, Nettles, Nwachukwu and their colleagues found that resveratrol is an effective inhibitor of interleukin 6 (IL-6), a pro-inflammatory protein that is part of the immune system (although IL-6 can be anti-inflammatory during exercise). High levels of IL-6 are also associated with poor breast cancer patient survival. According to the study, resveratrol regulates IL-6 without stimulating cell proliferation by altering a number of co-regulators of the .

Explore further: Research sheds light on what causes cells to divide

More information: "Resveratrol Modulates the Inflammatory Response via An Estrogen Receptor-Signal Integration Network," eLife, 2014. elifesciences.org/content/earl… 14/04/24/eLife.02057

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FMA
not rated yet Apr 29, 2014
About 6 to 8 weeks ago, there was an article suggesting resveratrol and aspirin together can work better and have synergy effect.

I have a "pimple" on my face for few years, but I did pay much attention about it. After I have taken the above formulation for few weeks it shrink quite a bit. Now I think it's not a pimple, it may be a "tumour" (it may not be cancerous, I hope). I think I will continue to take the formulation for another few months and conclusion is resveratrol (+aspirin) really works.
ironjustice
not rated yet Apr 30, 2014
It is thought resveratrols' iron chelating properties is what causes it to be so efficient.
"Researchers now convincingly show that, via its iron-chelating effects, resveratrol is able to cross barriers that protect the brain from entry of toxins (blood/brain barrier) and reduce oxidation (spoilage) of fats and increase the activity of protective antioxidant enzymes in the brain of healthy rodents"

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