Related topics: women · breast cancer · cancer cells · estrogen

Using E. coli to detect hormone disruptors in the environment

Endocrine disrupting chemicals (EDCs) have been implicated in the development of obesity, diabetes and cancer and are found in a wide array of products including pesticides, plastics and pharmaceuticals. EDCs are potentially ...

Protein structures give disease clues

Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially ...

New sensors streamline detection of estrogenic compounds

Researchers have engineered new sensors that fluoresce in the presence of compounds that interact with estrogen receptors in human cells. The sensors detect natural or human-made substances that alter estrogenic signaling ...

Clue to unusual drug-resistant breast cancers found

Researchers at the University of Illinois at Chicago College of Medicine have found how gene expression that may contribute to drug resistance is ramped up in unusual types of breast tumors. Their findings may offer new therapy ...

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Estrogen receptor

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. This article refers to the nuclear hormone receptor ER.

The main function of the estrogen receptor is as a DNA binding transcription factor that regulates gene expression. However, the estrogen receptor has additional functions independent of DNA binding.

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