Passing on the right antibodies: Protecting piglets from diarrhea

Aug 20, 2013
The first milk provides piglets with important antibodies. Credit: Vetmeduni Vienna/Worliczek

The parasite Cystoisospora suis affects suckling pigs causing severe intestinal problems, such as diarrhoea. Scientists at the University of Veterinary Medicine, Vienna (Vetmeduni) have now shown that antibodies against Cystoisospora suis are passed from mother to their piglets via the milk. Surprisingly however, the antibodies do not seem to protect the animals very efficiently. The results are presented in the current issue of the journal Veterinary Parasitology.

Like , new-born piglets have only poorly developed immune systems, although their resistance to disease is generally thought to be extremely important to their survival and growth. Unlike human babies, piglets do not receive antibodies via the placenta so they are even more reliant than humans on antibodies transferred in the colostrum, the first milk that mothers produce when giving birth. For the first few hours after birth, their intestinal walls are fairly permeable so large proteins such as antibodies can pass into the bloodstream and be transferred to different organs.

One of the most common causes of neonatal diarrhoea in piglets is coccidiosis, a severe of the intestinal tract caused by the Cystoisospora suis. Coccidiosis is associated with extensive destruction of the gut mucosa and thus with less efficient food uptake, causing reduced weight gain and to farmers. Infection with Cystoisospora suis results in heavy diarrhoea and may cause fatalities if secondary bacterial infections are present. For considerations as well as for economic reasons there is considerable interest in trying to control the disease.

The issue is being tackled by a junior research group at the Vetmeduni's Institute of Parasitology headed by Hanna Worliczek. The study authors Lukas Schwarz and colleagues have now examined the levels of antibodies against Cystoisospora suis that are transferred to piglets in the colostrum. The scientists were able to show that sows do indeed pass Cystoisospora antibodies on via the : maternal IgA, IgG and IgM were all found in the piglets' blood within a few hours of birth. Although high levels of the so-called IgG antibodies remained throughout the entire four weeks of the study, the other maternal antibodies disappeared within 2-3 weeks, by which time the piglets were producing their own antibodies.

Adult pigs acquire antibodies against Cystoisospora suis as a result of natural infections with the parasite, which they are usually able to clear without showing any symptoms. Surprisingly, though, these antibodies do not seem to protect the piglets against clinical signs of . As Worliczek says, "It is possible that the sows had been infected a long time ago and so no longer had sufficient levels of antibodies left to protect their piglets against the disease."

Interestingly, the new work suggests that IgA antibodies are involved in the immune response to Cystoisospora infection: piglets with higher levels of maternal IgA antibodies suffered from less severe diarrhoea than piglets with lower IgA concentrations. The Vetmeduni researchers are optimistic that a better understanding of immune reaction against Cystoisospora suis will lead to better protective measures. Worliczek explains that "The levels of anti-Cystoisospora IgA antibodies might provide a good correlate of protection against neonatal infection with the parasite. Now we need to find ways to boost sows' IgA levels and see whether they translate to healthier ."

Explore further: Bad reputation of crows demystified

More information: Schwarz, L., Joachim, A. and Worliczek, L., Transfer of Cystoisospora suis-specific colostral antibodies and their correlation with the course of neonatal porcine cystoisosporosis, Veterinary Parasitology. dx.doi.org/10.1016/j.vetpar.2013.07.007

add to favorites email to friend print save as pdf

Related Stories

Healthy piglets? Not with sulfonamides

Dec 05, 2011

Recent work from the University of Veterinary Medicine, Vienna confirms that sulfonamides can be used to control coccidiosis in piglets, although not without considerable effort and expense. In contrast, the drug toltrazuril ...

Recommended for you

Bad reputation of crows demystified

Jan 23, 2015

In literature, crows and ravens arebad omens and are associated with witches. Most people believe they steal, eat other birds' eggs and reduce the populations of other birds. But a new study, which has brought ...

How gerbils orient in the light of the setting sun

Jan 23, 2015

A light brown remains light brown: For gerbils, the fur color of their conspecifics appears identical under different lighting conditions. The ability of color constancy in rodents has been demonstrated for ...

Snack attack: Bears munch on ants and help plants grow

Jan 22, 2015

Tiny ants may seem like an odd food source for black bears, but the protein-packed bugs are a major part of some bears' diets and a crucial part of the food web that not only affects other bugs, but plants too.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.