Scientists propose new international cancer effort akin to Human Genome Project

Dec 02, 2010

Scientists are proposing an international effort, on the scale of the Human Genome Project (HGP), to identify all the proteins present in cancer cells. HGP was the international scientific research project that identified and mapped all the genes in humans. Within a decade, they believe, results of the new effort could provide cancer patients with more effective treatments customized to their own biology. The perspective appears in ACS' Journal of Proteome Research.

Cristobal Belda-Iniesta and colleagues point out that medicine already is moving toward individual treatments instead of a "one size fits all" strategy. Doctors currently use information from tissue biopsies, medical imaging, and other sources to select the most effective treatment for each patient.

Analyzing biomarkers in each patient would be a major advance, since these proteins could allow doctors to determine how a particular cancer might respond to a specific drug. Scientists already have identified hundreds of these cellular calling cards, and now must identify more and begin applying the knowledge in treating patients.

Accomplishing it will require an international effort to identify these cancer-related proteins with collaboration among hospitals, research centers, and governments from around the world. Doctors would collect blood samples from patients with the major forms of cancer prior to surgery or during drug treatment for cancer in order to profile the proteins associated with the success or failure of a specific treatment, with cancer's spread to distant sites in the body, and other factors. The results in improved treatments could begin to appear within 5 years of completing the project, they suggest.

Explore further: Olive oil more stable and healthful than seed oils for frying food

More information: "Translational Proteomics: What Can You Do for True Patients?" pubs.acs.org/doi/abs/10.1021/pr100853a

add to favorites email to friend print save as pdf

Related Stories

New biomarkers for predicting the spread of colon cancer

Jan 13, 2010

Scientists in China are reporting discovery of two proteins present in the blood, of people with colon cancer that may serve as the potential biomarkers for accurately predicting whether the disease will spread. ...

New cancer biomarker may herald personalised medicine

Mar 23, 2010

(PhysOrg.com) -- Scientists at Oxford University have led a study that shows how simple diagnostic tests to identify which patients will respond to which cancer drugs can be developed, potentially ushering in a new era of ...

Molecular detectors may refine cancer treatment

Jul 19, 2007

University of Florida researchers have successfully used molecular probes to detect subtle differences in leukemia cells from patient samples, an achievement that could lead to more effective ways to diagnose and treat cancer.

Cancer stem cells: know thine enemy

Dec 21, 2007

Stem cells -- popularly known as a source of biological rejuvenation -- may play harmful roles in the body, specifically in the growth and spread of cancer. Amongst the wildly dividing cells of a tumor, scientists have located ...

Recommended for you

Amino acids key to new gold leaching process

Oct 24, 2014

Curtin University scientists have developed a gold and copper extraction process using an amino acid–hydrogen peroxide system, which could provide an environmentally friendly and cheaper alternative to ...

Researchers create designer 'barrel' proteins

Oct 23, 2014

Proteins are long linear molecules that fold up to form well-defined 3D shapes. These 3D molecular architectures are essential for biological functions such as the elasticity of skin, the digestion of food, ...

User comments : 0