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Scientists at The Scripps Research Institute (TSRI) have developed a vaccine that blocks the pain-numbing effects of the opioid drugs oxycodone (oxy) and hydrocodone (hydro) in animal models. The vaccine also appears to decrease ...
Black light does more than make posters glow. Cornell researchers have developed a chemical tool to control inflammation that is activated by ultraviolet (UV) light.
Protein-based drugs are used in the treatment of every kind of malady, from cancer to heart disease to rheumatoid arthritis. But the proteins are almost always modified with chemical appendages that help them navigate through ...
While there have been advances in the treatment of hormone-driven breast cancer, resistance to these therapies remains a significant problem. Side effects, including an increased risk of uterine cancer among postmenopausal ...
An international team of computer scientists has for the first time developed a method to find antibiotics hidden in huge but still unexplored mass spectrometry datasets. They detailed their new method, called DEREPLICATOR, ...
(Phys.org)—A small team of researchers from Stanford University has synthesized the neurotoxin present in the skin of the poison dart frog. In their paper published in the journal Science, the team describes how they accomplished ...
New research at the University of Arkansas shows that arginine – one of 20 common amino acids – does not change its positive charge when inserted into the lipid environment of the cell membrane.
Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory have played a key role in discovering a new class of drug candidates that hold promise to combat antibiotic resistance. In a study led ...
Biochemists from Trinity College Dublin have solved an old mystery as to the cause of especially smelly camel urine, with implications for the millions of people affected by African parasites called trypanosomes. These parasites ...
The mesoporous material Upsalite is shown to inhibit growth of bacteria associated with acne and hospital acquired infections. In a study published in ACS Omega, researchers at Uppsala University have shown that the mesoporous ...
Just as a boat can be driven off course by a log in its path, a single, random mutation can send life in a new direction. That scenario, says University of Oregon biochemist Ken Prehoda, illustrates how a random mutation ...
A group of researchers led by Kazuya Kikuchi, professor at the Graduate School of Engineering, Osaka University, clarified the role of a N-glycan chain on glucose transporter type 4 (GLUT4) by developing a method for visualizing ...
Most antibiotics in use today are based on natural molecules produced by bacteria—and given the rise of antibiotic resistance, there's an urgent need to find more of them. Yet coaxing bacteria to produce new antibiotics ...
Translation of the genetic code in proteins is a central process in life and takes place in the ribosome, a giant molecule consisting of two subunits. This is where long chains of amino acids are formed like on an assembly ...
Ferroptosis is a recently discovered form of cell death, which is still only partially understood. Scientists at the Helmholtz Zentrum München have now identified an enzyme that plays a key role in generating the signal ...
A team of researchers from UCLA and the University of Illinois at Urbana-Champaign originally set out to discover and design antimicrobial peptides—short chains of amino acids that can kill bacteria by punching holes in ...
We leave behind trace chemicals, molecules and microbes on every object we touch. By sampling the molecules on cell phones, researchers at University of California San Diego School of Medicine and Skaggs School of Pharmacy ...
A multidisciplinary international team of scientists solved the mystery of a recently discovered type of controlled cell death, mapping the path to potential therapies for conditions ranging from radiation injury to cancer. ...
Synthetic biology allows scientists to design genetic circuits that can be placed in cells, giving them new functions such as producing drugs or other useful molecules. However, as these circuits become more complex, the ...
Researchers have developed a new method of switching the Dendra2 fluorescent protein from its green to red form. This phenomenon does not inflict damage to the cells under study, and can be used for a wide range of research. ...
In an industrial society, pollutants are everywhere—in the soil, in the air and absorbed in the bodies of most people. Unfortunately, exposure to environmental pollutants associated with chronic disease development is difficult ...
SA Young Tall Poppy of the Year, Flinders University's Dr Justin Chalker, has been part of an international research effort which opens the door to new drug development and a range of other applications in biochemistry.
For most invading bacteria, the bladder is not a friendly place.
Researchers from MIT and the University of California at Irvine have developed a new strategy to immunize against microbes that invade the gastrointestinal tract, including Salmonella, which causes more foodborne illness ...
An international research team led by the University of Leicester has made a breakthrough advance that could pave a new route for the development of anti-cancer drugs.
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Scientists at the University of Dundee have identified a 'molecular commando' which can be stealthily deployed to activate a hypoxic response, a process which can help to fight a range of conditions including stroke, angina, ...
Electron microscopy (EM), which uses particle beams of accelerated electrons to interrogate specimens, has long been a leading technology for revealing the shape and structure of the tiniest objects, from the cells which ...
A new type of lab-created protein could help create valuable new treatments for cancer, scientists report in a new paper.
It's the ultimate chicken-or-egg conundrum: What was the "mother" molecule that led to the formation of life? And how did it replicate itself? One prominent school of thought proposes that RNA is the answer to the first question. ...
Over the past few decades, many bacteria have become resistant to existing antibiotics, and few new drugs have emerged. A recent study from a U.K. commission on antimicrobial resistance estimated that by 2050, antibiotic-resistant ...
New work led by Carnegie's Steven Farber sheds light on how form follows function for intestinal cells responding to high-fat foods that are rich in cholesterol and triglycerides. Their findings are published in the Journal ...
Scientists at The Scripps Research Institute (TSRI) have developed a broadly useful method to unmask new functional features of human proteins.
By the time you reach the end of this sentence, RNA folding will have taken place in your body more than 10 quadrillion times. The folding of RNA is essential to life, yet because it happens so rapidly, researchers have difficulty ...
(Phys.org)—A team of researchers affiliated with several institutions in Australia has found that Tasmanian devil breast milk contains several types of antimicrobial peptides. In their paper published in the journal Scientific ...
A team of Vanderbilt scientists have genetically modified luciferase, the enzyme that produces bioluminescence, so that it acts as an optical sensor that records activity in brain cells.
Proteins often don't do anything in our cells by themselves. Their role in a given physiological process - good or bad - is typically determined by binding to one or more other proteins. So as researchers try to figure out ...
Cisplatin is one of the most widely used agents in cancer chemotherapy. Its mode of action is cross-linking of the DNA, which can kill cells. But which part of the genome is more affected, and which is less affected? A Chinese ...
Researchers have the clearest picture yet of the receptor that causes the "high" associated with marijuana. The three-dimensional image of cannabinoid receptor 1, revealed October 20 in Cell, reveals how molecules like THC ...
In a collaborative study, scientists from MIPT and JINR (Joint Institute for Nuclear Research) have increased the accuracy of detecting valuable protein crystals of just a few microns in size. These small crystals are now ...
In a paper published today in Nature Chemical Biology, a team of researchers from Uppsala University, the Broad Institute of MIT, Harvard, and AstraZeneca are presenting new insights into how larger-than-average molecules ...
Several of the more aggressive pathogens that infect humans can thrive in an oxygen-free environment of the human gut. These pathogens also have the ability to acquire the essential nutrient iron from an abundant cofactor, ...
A common bacterium that more than half of people have in their gut can use hydrogen gas present in the gastrointestinal tract to inject a cancer-causing toxin into otherwise healthy cells, according to a recently published ...
An unexpected source of inefficiency within a photosynthetic enzyme has been identified by scientists. The issue also adversely affects the performance of devices which are used to model artificial photosynthesis - a biomimicry ...
When you've got to go, but you're out there in space, zipped up in a spacesuit, with no toilet in sight and a crew of other astronauts around, what do you do?
We all know that when it rains, plants grow. When it doesn't, they don't.
In science, sometimes the best discoveries come when you're exploring something else entirely. That's the case with recent findings from the National Institute of Standards and Technology (NIST), where a research team has ...
Graphene, a two-dimensional form of carbon in sheets just one atom in thick, has been the subject of widespread research, in large part because of its unique combination of strength, electrical conductivity, and chemical ...
Every year, trade winds over the Sahara Desert sweep up huge plumes of mineral dust, transporting hundreds of teragrams—enough to fill 10 million dump trucks—across North Africa and over the Atlantic Ocean. This dust ...
The claws of coconut crabs have the strongest pinching force of any crustacean, according to a study published November 23, 2016 in the open-access journal PLOS ONE by Shin-ichiro Oka from Okinawa Churashima Foundation, Japan, ...
People have a remarkable ability to remember and recall events from the past, even when those events didn't hold any particular importance at the time they occurred. Now, researchers reporting in the journal Current Biology ...
"Mood ring materials" could play an important role in minimizing and mitigating damage to the nation's failing infrastructure.
A groundbreaking study of the virosphere of the most populous animals - those without backbones such as insects, spiders and worms and that live around our houses - has uncovered 1445 viruses, revealing people have only scratched ...
Reporting this week (Wednesday Nov. 23) in the journal Nature an international team led by British Antarctic Survey (BAS) explains that present-day thinning and retreat of Pine Island Glacier, one of the largest and fastest ...
A naturally occurring predatory bacterium is able to work with the immune system to clear multi-drug resistant Shigella infections in zebrafish, according to a study published today in Current Biology.
Piezoelectric sensors measure changes in pressure, acceleration, temperature, strain or force and are used in a vast array of devices important to everyday life. However, these sensors often can be limited by the "white noise" ...
The government wants smartphone makers to lock out most apps when the phone is being used by someone driving a car.
In the age of WikiLeaks, Russian hacks and increased government surveillance, many computer users are feeling increasingly worried about how best to protect their personal information—even if they aren't guarding state ...
Researchers have revealed new atomic-scale details about pesky deposits that can stop or slow chemical reactions vital to fuel production and other processes. This disruption to reactions is known as deactivation or poisoning.
A study co-led by the University of East Anglia (UEA) has found that people with genes for high educational achievement tend to marry, and have children with, people with similar DNA.
The study, published as the cover article in BioMed Central's Avian Research, led by the Earlham Institute and the Museum of Vertebrate Zoology at the University of California, explores the phylogenetic relationship between ...
Scientists at the U.S. Department of Energy's Ames Laboratory are being credited with creating the first intermetallic double salt with platinum.
(Phys.org)—A team of researchers from France, the U.S. and Italy has found evidence from the Tohoku-Oki earthquake that sensors that measure changes in gravity might offer a way to warn people of impending disaster faster ...
A new analysis of subsistence data collected in three Arctic communities underscores the importance of social ties and sharing among households.
Despite what you might think, evolution rarely happens because something is good for a species. Instead, natural selection favours genetic variants that are good for the individuals that possess them. This leads to a much ...
(Phys.org)—A team of researchers with the Universities of Roehampton and Birmingham in the U.K. has found a unique way to measure the energy spent by tree-dwelling apes when faced with gaps in a jungle canopy. In their ...
Although recent election coverage may suggest otherwise, research shows that people are more likely to use positive words than negative words on the whole in their communications. Behavioral scientists have extensively documented ...
How can quantum information be stored as long as possible? An important step forward in the development of quantum memories has been achieved by a research team of TU Wien.
An enterprising researcher from The University of Manchester has developed a prototype tool that could help transform the lives of the blind and visually impaired.
It only takes a few seconds for an employee of one of the world's leading hacking companies to take a locked smartphone and pull the data from it.
Men and women don't communicate much differently from each other, at least when they get the same training and are working on the same type of written assignment. The findings come amid frequent studies that have discovered ...
Scientists at Washington University in St. Louis isolated an enzyme that controls the levels of two plant hormones simultaneously, linking the molecular pathways for growth and defense.
Education scholars say youth are duped by sponsored content and don't always recognize political bias of social messages.
The Northeastern coast of the USA could be struck by more frequent and more powerful hurricanes in the future due to shifting weather patterns, according to new research.
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