Two RIKEN researchers have discovered how, during cell division, one enzyme helps facilitate the tightly coordinated reorganization of chromosomal DNA into compact structures that can be evenly divided amongst the two resulting ...
Cell & Microbiology
Sep 8, 2021
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Important advances in the understanding of DNA topoisomerases are discussed in a new review led by John Innes Centre researchers.
Cell & Microbiology
Mar 16, 2021
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Scientists from Skoltech and MSU have investigated antibiotic nybomycin that could prove effective against bacteria resistant to other antibiotics. Their research was published in the journal Antimicrobial Agents and Chemotherapy.
Cell & Microbiology
Mar 4, 2021
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The final stage of DNA replication—"termination"—occurs when two DNA copy machines advance upon each other and unwind the final stretch of DNA. This process occurs about 60,000 times per human cell cycle and is crucial ...
Cell & Microbiology
Oct 28, 2019
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11
Antibiotics have saved many lives by rescuing patients with bacterial or fungal infections, but these valuable drugs also have a dark side. As with most clinical drugs, many antibiotics can also have undesired effects on ...
Cell & Microbiology
Oct 1, 2018
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219
DNA is a lengthy molecule—approximately 1,000-fold longer than the cell in which it resides—so it can't be jammed in haphazardly. Rather, it must be neatly organized so proteins involved in critical processes can access ...
Cell & Microbiology
Sep 18, 2018
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Structural biologists at the Friedrich Miescher Institute for Biomedical Research have resolved the 3D structure of a protein machine that plays an important part in the maintenance of genomic stability. They have revealed ...
Cell & Microbiology
Feb 21, 2014
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A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs.
Cell & Microbiology
Nov 15, 2012
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A team of Penn State scientists has shed light on the processes that lead to certain human DNA mutations that are implicated in hundreds of inherited diseases such as tuberous sclerosis and neurofibromatosis type 1. The ...
Cell & Microbiology
Jul 2, 2009
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