Using single-antibodies as a new tool to build bio-circuitry

By using single-antibodies, Professor Hirohide Saito (Department of Life Science Frontiers) and his team of researchers, Shodai Komatsu and Assistant Professor Hirohisa Ohno, have developed a novel system to control gene ...

Weaker transcription factors are better when they work together

Bioengineers can tailor the genomes of cells to create "cellular therapies" that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors that can throw the switch ...

A new control switch could make RNA therapies easier to program

Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene. Their approach could make it possible to create targeted therapies for cancer and other diseases, by ensuring that synthetic ...

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