Plants fix DNA differently from animals

In mammalian cells, the transcription factor p53 most responsible for healthy growth of the organism. The equivalent in plants is Suppressor Of Gamma Response 1 (SOG1), a factor that does not share a common evolutionary ancestor ...

Scientists improve DNA transfer in gene therapy

Parkinson's disease, Huntington's disease, cystic fibrosis and many other fatal human diseases are hereditary. Many cancers and cardiovascular diseases are also caused by genetic defects. Gene therapy is a promising possibility ...

Nanoscale platform aims to control protein levels

A nanoscale antibody first found in camels combined with a protein-degrading molecule is an effective new platform to control protein levels in cells, according to Rice University scientists. The technique could aid fundamental ...

Using networks to understand tissue-specific gene regulation

Researchers at Brigham and Women's Hospital have discerned that different tissue functions arise from a core biological machinery that is largely shared across tissues, rather than from their own individual regulators. In ...

Matchmaking with consequences

Most human tumours have one thing in common: They harbour drastically increased amounts of the so-called Myc proteins. Animal experiments show that such high Myc concentrations contribute to causing cancer. But Myc proteins ...

Plant cells survive but stop dividing upon DNA damage

The cell cycle is the system through which a cell grows and divides. It is also how a cell passes its DNA to its progeny and is why the cell cycle ceases if the DNA is damaged, as otherwise it risks passing this damage to ...

New CRISPR tool targets RNA in mammalian cells

Researchers from the Broad Institute of MIT and Harvard have shown that a CRISPR-based editing system can cut and bind RNA in mammalian cells. In a paper out this week in Nature, the team used CRISPR-Cas13, which the researchers ...

Scientists use CRISPR technology to change flower colour

In a world-first, Japanese scientists have used the revolutionary CRISPR, or CRISPR/Cas9, genome- editing tool to change flower colour in an ornamental plant. Researchers from the University of Tsukuba, the National Agriculture ...

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