Plan B for cholesterol transport

Cholesterol is a vital cell building block in humans and animals, and an integral part of the so-called cell membrane. This boundary layer separates the interior of the cell from the neighboring cells and the surrounding ...

New software brings lower-resolution cryo-EM maps into focus

Cryo-electron microscopy is now the most popular method for determining protein structures, which helps researchers develop drugs for different kinds of ailments. Over the last several decades, it has replaced X-ray crystallography ...

How nature builds hydrogen-producing enzymes

A team from Ruhr-Universität Bochum and the University of Oxford has discovered how hydrogen-producing enzymes, called hydrogenases, are activated during their biosynthesis. They showed how the cofactor—part of the active ...

Frog protein may mitigate dangers posed by toxic marine microbes

A new study from UC San Francisco suggests that a protein found in the common bullfrog may one day be used to detect and neutralize a poisonous compound produced by red tides and other harmful algal blooms. The discovery ...

Nuclear pore complex outer rings: No longer 'one size fits all'

In eukaryotic cells, the nucleus is walled off from the rest of the cell by the nuclear envelope. All transport into and out of the nucleus occurs via cylindrical channels called nuclear pore complexes (NPCs) that penetrate ...

'Fishing a line' coupled with clockwork for daily rhythm

Organisms on this planet, including human beings, exhibit a biological rhythm that repeats about every 24 hours to adapt to the daily environmental alteration caused by the rotation of the earth. This circadian rhythm is ...

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