Related topics: stem cells

Changing pluripotent stem cells to differentiated cells

Stem cells are an effective tool for repairing or replacing damaged or diseased tissues, but only if they can be reliably developed from their flexible 'pluripotent' state into a mature 'differentiated' state. A*STAR researchers ...

Controls of specialization unraveled

Two phases of the cell cycle of human embryonic stem cells have been shown, for the first time, to actively employ pathways that maintain pluripotency—the potential to develop into almost any type of cell in the body.

Production of iPS cells: Discovery of the fifth element

Since 2006, research has succeeded in generating, from specialised adult cells, induced pluripotent cells (iPS cells), with huge potential applications, particularly for regenerative medicine. However, the process has still ...

Sall4 is required for DNA repair in stem cells

A protein that helps embryonic stem cells (ESCs) retain their identity also promotes DNA repair, according to a study in The Journal of Cell Biology. The findings raise the possibility that the protein, Sall4, performs a ...

Controlling the transition between generations

Rafal Ciosk and his group at the FMI have identified an important regulator of the transition from germ cell to embryonic cell. LIN-41 prevents the premature onset of embryonic transcription in oocytes poised for embryonic ...

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