The last time you popped a pill for a headache or a stuffy nose, did you think about how the medication actually alleviates your pain or unblocks your stuffy nose? Curing a disease is a complex process and involves understanding ...
Biochemistry
Jan 14, 2013
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Readers of the top-ranked scientific journals Science and Nature might have noticed a recent wave of articles, most recently in the July 13, 2012 issue of Science, with deep importance for biology and medicine. These papers, ...
Cell & Microbiology
Jul 12, 2012
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(PhysOrg.com) -- New information that could help in the fight against asthma has been obtained by an international collaboration of scientists utilizing the U.S. Department of Energy’s Advanced Photon Source at Argonne ...
Biochemistry
Mar 18, 2011
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Using a computer simulation of an important receptor, EPFL scientists have discovered a novel binding site for natural ligands and drugs. The new site might be present on other receptors and can be exploited in novel treatments ...
Biochemistry
Jul 26, 2018
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A multi-institutional project to understand one of the major targets of human drug design has produced new insights into how structural communication works in a cell component called a G protein-coupled receptor (GPCRs), ...
Biochemistry
Apr 12, 2018
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Scientists at Heptares Therapeutics have published the first high-resolution X-ray crystal structure of the complement C5a receptor (a G protein-coupled receptor, GPCR) binding a small molecule allosteric antagonist.
Biochemistry
Jan 4, 2018
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From a drug perspective, G protein-coupled receptors are the most utilised cell receptors in the body. They are uniquely accessible at the cell surface, and a third of all drugs sold in the US target them.
Biochemistry
Oct 31, 2017
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G protein-coupled receptors are the key target of a large number of drugs. Würzburg scientists have now been able to show more precisely how these receptors act in the cell interior.
Biochemistry
Sep 5, 2017
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"Pain begone!" In order to send out this signal, the human body produces tiny messenger molecules that dock to certain receptors. Using traditional biochemical methods, this interaction between the messengers, so-called enkephalins, ...
Biochemistry
Jul 9, 2013
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Last year's Nobel Prize in Chemistry – shared by Stanford School of Medicine Professor Brian Kobilka and Robert Lefkowitz of Duke University – recognized groundbreaking research in G protein-coupled receptors (GPCRs). ...
General Physics
May 10, 2013
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