After decades of speculation, researchers have demonstrated that a classical DNA repair enzyme also binds to RNA, affecting blood cell development.
Biotechnology
Feb 27, 2020
0
18
One of the key features in the evolution of more complex organisms is the emergence of allosteric regulation. Allostery is a process by which a protein's activity can be modulated by binding an effector molecule distal to ...
Biochemistry
Feb 24, 2020
0
27
Researchers at the University of Copenhagen have used highly sophisticated molecular analyses to identify key proteins in the signaling pathways that cancers use to spread in the body. The study could help in personalizing ...
Cell & Microbiology
Oct 4, 2019
0
45
"Resurrecting" the ancestors of key proteins yields evolutionary insights into their role in human cells and in most cancers, a new study finds.
Molecular & Computational biology
Aug 13, 2019
0
58
G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of ...
Molecular & Computational biology
Apr 15, 2019
0
7
Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.
Biochemistry
Apr 4, 2019
0
7
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and ...
Biochemistry
Mar 20, 2019
0
186
Lysophospholipids (LysoPLs) are potent cellular signaling biomolecules that also maintain the structure, shape and fluidity of cell membranes.
Oncology & Cancer
Feb 18, 2019
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3
Cellular signaling pathways involved in everything from the proliferation of fatty tissue to the death of neurons in the brain are tightly regulated by "cascades" of sequentially activated enzymes, MAP kinases. These enzymes ...
Cell & Microbiology
Jan 21, 2019
0
4
Scientists from VIB and Ghent University under the guidance of Prof. Dr. Jenny Russinova have uncovered a novel mechanism in plants that controls an important decision step in stomatal lineage to divide asymmetrically or ...
Plants & Animals
Nov 15, 2018
0
15
