The yin and yang of cell signaling

February 18, 2019 by Liz Entman, Vanderbilt University

Lysophospholipids (LysoPLs) are potent cellular signaling biomolecules that also maintain the structure, shape and fluidity of cell membranes.

Imbalance in LysoPL levels has been associated with cell proliferation, inflammatory processes and neurological diseases.

In mammals, cellular levels of LysoPLs are finely regulated primarily by the enzymes lysophospholipase (LYPLA) 1 and 2. Although the enzymes are similar in their and structures, they display moderate substrate specificity.

To better understand their role in LysoPL metabolism, Lawrence Marnett, PhD, and colleagues used CRISPR-Cas9 technology to generate stable knock-outs of LYPLA1 and/or LYPLA2 in mouse neuroblastoma cell lines.

Their work, published this month in the Journal of Lipid Research, showed that LYPLA1 and LYPLA2 compensated for the loss of each other and cooperatively maintained LysoPL levels in the cells.

However, deletion of both enzymes led to dramatically increased LysoPL levels and increased activation of the mitogen-activated (MAPK) signaling pathway, which has been implicated in development of human neurodegenerative diseases and cancer.

Explore further: Molecular mechanisms behind AICAr drug; impact on ALL

More information: James A. Wepy et al. Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling, Journal of Lipid Research (2018). DOI: 10.1194/jlr.M087890

Related Stories

Molecular mechanisms behind AICAr drug; impact on ALL

January 31, 2019

AICAr (5-amino-4-imidazolecarboxamide riboside, also called Acadesine) has been found to inhibit cell proliferation and has cytotoxic potential for childhood acute lymphoblastic leukemia (ALL) cells. Much of the drug's cytotoxic ...

Study shows how BPA may affect inflammatory breast cancer

March 29, 2017

The chemical bisphenol A, or BPA, appears to aid the survival of inflammatory breast cancer cells, revealing a potential mechanism for how the disease grows, according to a study led by researchers in the Department of Surgery ...

Study offers new approach to starve p53 deficient tumors

May 3, 2018

One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete for the ever-diminishing supply of nutrients in the surrounding environment ...

Recommended for you

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.