Scientists develop novel method to monitor molecular aggregation

Chiral molecules are defined as molecules that are non-superimposable on their mirror images, much like that of left and right human hand bone structure. There are many examples of chiral molecules in nature, including proteins ...

Novel probe for metabolic diseases

NUS pharmaceutical scientists have developed a simple, yet highly sensitive probe to detect the fat mass and obesity-associated protein (FTO) levels in cells. This can potentially help in the early detection and diagnosis ...

New computational method for drug discovery

HITS researchers developed tauRAMD, a tool to predict drug-target residence times from short simulations. The method is illustrated on the cover page of July 2018 issue of the Journal of Chemical Theory and Computation, software ...

Simpler model gets to the point with proteins

Computational models have come a long way in their ability to simulate the most basic biological processes, such as how proteins fold. A new technique created by Rice University researchers should enable scientists to model ...

Partial mechanical unfolding may regulate protein function

A study carried out as a collaborative approach between University of Tampere, Finland, and Imperial College London has shown that mechanically regulated proteins talin and α-catenin have stable intermediates during mechanical ...

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