Many anti-cancer drugs block signals in cancer cells that help degenerated cells to multiply uncontrollably and detach from tissue. For example, blocking the signaling protein FAK, a so-called kinase, causes breast cancer ...
Biochemistry
Jan 28, 2021
0
16
A chemical probe molecule—a "first gen" molecule that can be used for drug development—that targets a host cell's protein quality control pathways can dramatically reduce infection by Dengue and Zika viruses. The research ...
Cell & Microbiology
Jan 27, 2021
0
35
A new method of identifying molecular targets to fight disease could help accelerate future drug development new Griffith University research published in Scientific Reports has found.
Cell & Microbiology
Jan 27, 2021
0
17
PARP inhibitors are recently developed drugs that have shown great promise against some types of ovarian, breast, prostate and pancreatic cancer, but many patients' tumors develop resistance to the drugs. Now researchers ...
Cell & Microbiology
Jan 19, 2021
0
24
Researchers from Duke-NUS Medical School in Singapore and Columbia University in the U.S. have solved how Wnt proteins, which play a fundamental role in cell proliferation and differentiation, hitch a ride to travel from ...
Cell & Microbiology
Jan 12, 2021
0
32
Scientists have used computer modeling to identify potential 'vulnerable sites' on a key protein found in coronavirus—paving the way for possible new drug treatments in the future.
Cell & Microbiology
Jan 7, 2021
0
131
It typically takes many years of experiments to develop a new medicine. Although vaccines to protect against disease from the novel coronavirus are starting to reach clinics around the world, patients and doctors will still ...
Biotechnology
Dec 16, 2020
0
29
Imagine trying to throw a bullseye when the dartboard lies buried within a crumpled box. That's the challenge faced by scientists working to make new medicines for some 'undruggable' diseases, including a type of metastatic ...
Biochemistry
Dec 15, 2020
0
49
Knowing precisely where proteins are frustrated could go a long way toward making better drugs.
Biochemistry
Nov 23, 2020
0
149
Until now, scientists typically studied the changes of proteins and their roles in the cell by using a fluorescent tag to label and follow one protein at a time. This approach limited the number of proteins that could be ...
Biotechnology
Nov 17, 2020
0
177
