Current drugs block the actions of only about a quarter of known disease-causing proteins, but Yale University researchers have developed a technology capable of not just inhibiting, but destroying every protein it targets.
Biochemistry
Jun 11, 2015
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86
Biochemists from Trinity College Dublin have devised a new technique that will make the difficult but critical job of blueprinting certain proteins considerably faster, easier and cheaper.
Biochemistry
Jun 5, 2015
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52
Scientists have discovered an extraordinary protein-cutting enzyme that has also evolved to glue proteins together, a finding that may be valuable in the production of therapeutic drugs.
Biochemistry
May 8, 2015
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39
A new study shows that it is possible to use an imaging technique called cryo-electron microscopy (cryo-EM) to view, in near-atomic detail, the architecture of a metabolic enzyme bound to a drug that blocks its activity. ...
General Physics
May 7, 2015
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56
Using DESY's ultra bright X-ray source PETRA III, scientists have resolved the molecular structure of two promising drug candidates from the new group of Spiegelmers for the first time. The results provide a deeper understanding ...
Biochemistry
Apr 22, 2015
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17
Most of today's anticancer drugs target the DNA or proteins in tumor cells, but a new discovery by University of California, Berkeley, scientists unveils a whole new set of potential targets: the RNA intermediaries between ...
Cell & Microbiology
Apr 6, 2015
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27
An international team of researchers has shed light on the molecular mechanism behind the importance of water for functional protein dynamics. The scientists have discovered that water's ability to flow on the surface of ...
Biochemistry
Mar 17, 2015
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53
Every cell is encapsulated and protected by a thin membrane made of greasy molecules called lipids. Assemblies of equally greasy protein molecules span the membrane, forming passageways that control the flow of signaling ...
Cell & Microbiology
Jan 7, 2015
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16
A major challenge faced by the pharmaceutical industry has been how to rationally design and select protein molecules to create effective biologic drug therapies while reducing unintended side effects - a challenge that has ...
Biochemistry
Nov 18, 2014
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0
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery—it is extremely ...
Biotechnology
Nov 17, 2014
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