A team of scientists has created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin receptor, as well as vulnerable ...
Biochemistry
Mar 25, 2022
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24
In a structural analysis that could help inform efforts to develop new drugs for treating a myriad of diseases, RIKEN biologists have shed light on how the interaction between key signaling proteins and their regulatory partners ...
Cell & Microbiology
Mar 15, 2022
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37
The amount of structural data on protein drug targets continues to grow. However, successfully mining this data to form testable hypotheses that drive drug discovery can prove challenging. Selectivity for the target protein ...
Biochemistry
Mar 2, 2022
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11
The job of a protein hub inside the nucleus of a cell is similar to that of a chef in a kitchen. Both need to manage multiple tasks efficiently for a successful outcome. For the chef, if they spend too much time chopping ...
Cell & Microbiology
Feb 23, 2022
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34
A new study from the University of Eastern Finland and the University of Tübingen helps to explain what defines how long a drug molecule stays bound to its target.
Molecular & Computational biology
Jan 28, 2022
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11
Two researchers from Skoltech and McGill University have published a review of the promising research field known as structural proteomics in the journal Chemical Reviews. This field combines protein chemistry and mass spectrometry, ...
Biochemistry
Jan 27, 2022
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57
Protein drugs are widely used as pharmaceutical agents to treat a range of disorders. However, most of these drugs are not very stable and are only retained in the blood circulation for a limited period, which minimizes their ...
Biotechnology
Jan 25, 2022
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16
A mutated protein causes the genetic disease cystic fibrosis. Now, researchers have solved the structure of the protein and how certain drugs bind to it, unveiling their mode of action.
Cell & Microbiology
Jan 7, 2022
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590
A study by researchers affiliated with institutions in Brazil, Germany and Finland proposes a new standard for computer simulation that promises to accelerate the search for novel bioactive compounds against the virus that ...
Molecular & Computational biology
Dec 8, 2021
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12
The body must constantly defend itself against bacteria and viruses. It generates millions of different antibodies, which are selected to recognize the enemy and trigger the best possible immune response. Scientists use these ...
Biochemistry
Dec 6, 2021
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30
