Information generated by screening tools, readily available therapies and potential pathways to drug development are the cornerstone of informed clinical research and clinical trial design. In a new review in the August 2017 ...
Cell & Microbiology
Jul 19, 2017
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3
A single-molecule imaging technique, called protein-induced fluorescence enhancement (PIFE), has gained traction in recent years as a popular tool for observing DNA–protein interactions with nanometer precision. Yet, according ...
Biochemistry
Jul 24, 2019
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35
Many pharmaceuticals work by targeting what are known as 'G-protein-coupled receptors.' In a new study, scientists from Uppsala University describe how they have been able to predict how special molecules that can be used ...
Biochemistry
Jun 24, 2020
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44
Scientists have developed DIProT, an innovative, user-friendly toolkit for protein design. The toolkit utilizes a non-autoregressive deep generative model to address the protein inverse folding problem, integrating human ...
Biotechnology
May 20, 2024
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1
Chemists at UC San Diego have created an "adaptive protein crystal" with a counterintuitive and potentially useful property: When stretched in one direction, the material thickens in the perpendicular direction, rather than ...
Materials Science
May 2, 2016
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16
According to a recently published research paper, an approach has been developed to create artificial allosteric sites (where by binding an effector molecule, activity at the distal active site is regulated) in protein complexes. ...
Biochemistry
Jul 6, 2023
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3
David Baker's group at the University of Washington, Seattle, U.S., have developed a novel deep learning method, RoseTTAFold All-Atom (RFAA), for prediction and design of complexes of proteins, small molecules, and nucleic ...
Biotechnology
Mar 11, 2024
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1
Researchers at the University of Eastern Finland have developed novel antibacterial compounds, focusing on the role of LsrK kinase. LsrK kinase is a protein involved in bacterial communication. In a new study published in ...
Biochemistry
Nov 1, 2018
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73
Northwestern Medicine investigators have solved a challenging protein design puzzle using a unique high-throughput approach, according to a study published in Proceedings of the National Academy of Sciences.
Molecular & Computational biology
Oct 28, 2022
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90
A team that includes Rutgers scientists has designed a synthetic protein that quickly detects molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction and could be used ...
Biochemistry
Sep 1, 2022
0
13
