A catalyst for electronically controlled C–H functionalization

The Chirik Group at the Princeton Department of Chemistry is chipping away at one of the great challenges of metal-catalyzed C–H functionalization with a new method that uses a cobalt catalyst to differentiate between bonds ...

New method reveals folding speed limit of helical membrane proteins

Membrane proteins play a pivotal role in various cellular functions and are key targets for pharmaceutical interventions. In fact, approximately 60% of drugs currently available on the market target these specific proteins. ...

Breakthrough in β-lactam synthesis using nickel catalysts

Led by Director Chang Sukbok, scientists from the Center for Catalytic Hydrocarbon Functionalizations within the Institute for Basic Science (IBS) have made a significant advancement in the synthesis of β-lactam scaffolds, ...

New stapling method solves floppy peptide problem

In a cutting-edge discovery, published in the Journal of the American Chemical Society, Florey scientists have solved a long-standing problem: the need for an affordable, simple way to make peptide-based drugs that hold their ...

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