The inheritance, not only of DNA, but of changes to proteins that package it, maintains the identity of cells as they multiply, a new study finds.
Cell & Microbiology
Oct 31, 2019
0
95
UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...
Molecular & Computational biology
May 30, 2019
0
82
Two scientists at the Johns Hopkins University School of Medicine have unraveled aspects of how DNA organizes and preserves genetic information. Newly published research by Cynthia Wolberger, Ph.D., and James Berger, Ph.D., ...
Molecular & Computational biology
May 22, 2019
0
6
The way DNA folds largely determines which genes are read out. John van Noort and his group have quantified how easily rolled-up DNA parts stack. This costs less energy than previously assumed. Publication in Biophysical ...
Biochemistry
Nov 12, 2018
0
23
LMU researchers have, for the first time, systematically determined the positioning of the packing units of the fruit fly genome and discovered a new protein that defines their relationship to the DNA sequence.
Plants & Animals
Nov 5, 2018
0
11
A team of researchers at the University of Utah has found that nucleosomes can inhibit CRISPR/Cas9 cleavage efficiency. In their paper published in Proceedings of the National Academy of Sciences, the group describes testing ...
In the cell nucleus, the genomic DNA is packaged into a tightly condensed form, which is referred to as chromatin. The basic unit of chromatin organization is the nucleosome, a DNA-protein complex consisting of a defined ...
Cell & Microbiology
Sep 4, 2018
0
11
In eukaryotic cells, linear genetic DNA wraps around histones to form stable nucleosomes that further assemble to form chromatins. Nucleosomes represent big barriers to the transcription machine RNA polymerase.
Cell & Microbiology
Jul 23, 2018
0
11
A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. The method, ...
Cell & Microbiology
Jul 12, 2018
2
128
A protein complex called facilitates chromatin transcription (FACT) plays a role in DNA packing within a nucleus, as well as in oncogenesis. A team of scientists from MSU, working in cooperation with foreign colleagues, have ...
Cell & Microbiology
May 28, 2018
0
6
