The way DNA folds largely determines which genes are read out. John van Noort and his group have quantified how easily rolled-up DNA parts stack. This costs less energy than previously assumed. Publication in Biophysical ...
Biochemistry
Nov 12, 2018
0
23
LMU researchers have, for the first time, systematically determined the positioning of the packing units of the fruit fly genome and discovered a new protein that defines their relationship to the DNA sequence.
Plants & Animals
Nov 5, 2018
0
11
A team of researchers at the University of Utah has found that nucleosomes can inhibit CRISPR/Cas9 cleavage efficiency. In their paper published in Proceedings of the National Academy of Sciences, the group describes testing ...
In the cell nucleus, the genomic DNA is packaged into a tightly condensed form, which is referred to as chromatin. The basic unit of chromatin organization is the nucleosome, a DNA-protein complex consisting of a defined ...
Cell & Microbiology
Sep 4, 2018
0
11
In eukaryotic cells, linear genetic DNA wraps around histones to form stable nucleosomes that further assemble to form chromatins. Nucleosomes represent big barriers to the transcription machine RNA polymerase.
Cell & Microbiology
Jul 23, 2018
0
11
A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. The method, ...
Cell & Microbiology
Jul 12, 2018
2
128
Until human genes are activated, they are blocked by structures known as nucleosomes, components that serve to package DNA inside cells.
Biotechnology
May 14, 2018
0
144
DNA is tightly packed into the nucleus of a cell. Nevertheless, the cellular machinery needs to constantly access the genomic information. An LMU team now reveals the inner workings of a molecular motor made of proteins which ...
Cell & Microbiology
Apr 12, 2018
6
69
In cells, proteins tightly package the long thread of DNA into pearl necklace-like complexes known as chromatin. Scientists at EPFL show for the first time how chromatin moves, answering longstanding questions about how its ...
Cell & Microbiology
Jan 18, 2018
0
21
A fertilized human egg develops into multiple tissues, organs and about 200 distinct cell types. Each cell type has the same genes, but they are expressed differently during development and in mature cells.
Cell & Microbiology
Aug 30, 2017
0
199
