Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for Molecular Biomedicine in Münster (Germany) used computer simulations to reveal in atomic detail how a short piece of DNA ...
Biotechnology
Jun 3, 2021
0
14
Northwestern Medicine scientists have developed a new method to analyze the protein composition of intact nucleosomes without losing combinatorial information present in chromatin. The technique, called Nuc-MS, could help ...
Biotechnology
May 24, 2021
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12
Gene editing with CRISPR enzymes inside living cells could become more effective and accurate after researchers at The University of Texas at Austin unveiled how inner workings can help or hinder the process.
Biotechnology
Mar 10, 2021
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107
Chromatin remodelers are needed to take nucleosomes away from DNA in order to make room for transcription factors to bind, and regulate the activity of our genes. It has been unclear how dynamic this process is. Researchers ...
Evolution
Feb 9, 2021
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7
The nuclear receptor–binding SET Domain (NSD) family protein is closely connected with many cancers. However, their molecular mechanism remains unknown.
Biotechnology
Dec 24, 2020
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193
One feature of cell division has long puzzled scientists. The nucleus briefly disappears, leaving the cell's DNA exposed. Normally, bare DNA indicates a viral infection and triggers enzymatic alarms that alert the immune ...
Cell & Microbiology
Sep 15, 2020
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78
New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells—including cancer cells—regulate their genes.
Molecular & Computational biology
Jun 4, 2020
0
113
The DNA of a single cell is two to three meters long end-to-end. To fit in the nucleus and function correctly, DNA is packaged around specialized proteins. These DNA-protein complexes are called nucleosomes, and they are ...
Biotechnology
Nov 21, 2019
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126
The inheritance, not only of DNA, but of changes to proteins that package it, maintains the identity of cells as they multiply, a new study finds.
Cell & Microbiology
Oct 31, 2019
0
95
UV light damages the DNA of skin cells, which can lead to skin cancer. But this process is counteracted by DNA repair machinery, acting as a molecular sunscreen. It has been unclear, however, how repair proteins work on DNA ...
Molecular & Computational biology
May 30, 2019
0
82
