Biologists design a plug-and-play controller for gene expression

Researchers from two University of Texas System institutions have engineered biological components that can rewire genetic response pathways, creating a template for designing new cellular behaviors with wide-ranging potential ...

Protein production efficiency can be predicted by gene sequence

Today, thousands of databases with biological data are publicly available. They include data on gene and protein sequences and detailed measurements of different cellular parameters, such as the exact quantities of all proteins ...

Open database encapsulates worldwide knowledge of human metabolism

An international research consortium, spearheaded by the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg, has developed a database that is unique in the world: the Virtual Metabolic Human ...

Hunt for interesting metabolites with the antiSMASH database

Scientists who hunt for interesting bacterial metabolites using the online tool antiSMASH now have the opportunity to use an antiSMASH database with pre-calculated results of nearly 25,000 bacterial genomes. This database ...

New approach on the use of big data in clinical decision support

A new computational approach that allows the identification of molecular alterations associated with prognosis and resistance to therapy of different types of cancer was developed by the research group led by Nuno Barbosa ...

Gene cluster identification made easy through data mining

An updated web server will improve analysis of genetic material. This will help researchers optimise bacteria for the industrial production of novel antibiotics, vitamins and food-related compounds.

Supercoil me! The art of knotted DNA maintenance

Even living cells have their own tangled problems to solve. They involve knots that arise accidentally in DNA and that can comprise its functionality. Researchers now suggest that the DNA propensity to be supercoiled, just ...

Quality control is vital for the energy production of cells

Mitochondria generate most of the energy cells need through a respiratory chain for which they must produce their own proteins. The research group of Associate Professor Henna Tyynismaa, University of Helsinki, Finland, has ...

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