Aggregation of proteins in cells may result in diseases

Changes in the structure of proteins can lead to various diseases, such as Alzheimer's, type 2 diabetes and corneal dystrophy. A research team from Aarhus University has now discovered how a particular protein can damage ...

Appearance of cystic fibrosis at the molecular scale

Despite remarkable medical advances over the last years, cystic fibrosis remains the most prevalent lethal genetic disease. It is due to mutations in the CFTR protein which is normally required to maintain proper fluid balances ...

Team solves structure of key mTORC1 activator

A research team led by scientists at the Whitehead Institute has described the structure of a key protein complex that helps activate mTORC1, a master growth regulator that enables cells to quickly respond to changing nutrient ...

Human Argonaute proteins: To slice or not to slice?

What makes one Argonaute a slicer and another one not? Human Argonaute proteins are key players in the gene regulation process known as RNA interference, RNAi. Professor Joshua-Tor's group of Cold Spring Harbor Laboratory ...

A mutated eye offers a glimpse of a key protein for preventing cancer

About 15 years ago, a group of researchers discovered mutant zebrafish. The eyes of these zebrafish did not develop correctly, resulting in significantly smaller eyes than those of wild zebrafish. Now, one of these researchers—Prof. ...

Preventing resistance in cancer therapy

The latest developmental drugs, particularly for use in oncology, rely on the targeted degradation of harmful pathogenic proteins. In a recent study published in Nature Chemical Biology, researchers at CeMM, the Research ...

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