All life on earth evolved multiple layers and networks of ensuring survival upon catastrophic events. Even cells have their emergency plan: the heat shock response. Triggered by multiple stress stimuli such as heat, toxins, ...
Cell & Microbiology
Feb 5, 2021
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84
For decades, molecular biologists studying a class of molecular chaperones known as heat shock proteins (Hsp70s) have relied on the Hsp70s found in bacteria as the model system. Now one of the world's experts on the molecule ...
Biochemistry
Nov 9, 2018
0
54
New research at the University of Chicago has found that the same machinery used by mammalian cells to drive cellular differentiation also plays a critical role in activating genes in yeast in response to environmental stress.
Cell & Microbiology
Nov 22, 2022
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68
Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using chaperones to enable their uncontrolled growth. Now a team of biochemists ...
Biochemistry
Dec 6, 2012
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1
In a new study published in Nature Chemical Biology, researchers at Children's Hospital of Philadelphia (CHOP) have revealed the molecular mechanics of a cell-surface molecule that is a potential immunotherapy target. Using ...
Biochemistry
Jun 20, 2022
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92
The chaperone protein Grp94 can interfere with the clearance of another protein known to cause the glaucoma when mutated, a new study led by researchers at the University of South Florida has found. Using a cell model, the ...
Biochemistry
Oct 9, 2012
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0
Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer's.
Cell & Microbiology
May 11, 2023
0
16
Published in the Molecular Cell journal on July 19, a research study out of the Hatters Laboratory showed inappropriate protein aggregation is linked to poor outcomes for cell health and survival—especially in neurons in ...
Cell & Microbiology
Jul 19, 2022
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16
Proteins are the workhorses of our cells, carrying out essential tasks to keep our cells – and our bodies – functioning properly. But proteins can only do their jobs if they fold into the right shape.
Cell & Microbiology
Nov 28, 2018
1
13
Researchers at the University of Freiburg report a mechanism inside cells that transports proteins to the mitochondria. Their research has now been published in the science journal Cell Reports.
Cell & Microbiology
Nov 26, 2018
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4
