The subtle dance of atoms influences enzyme activity

Infinitesimal fluctuations occurring on the milli- and even nano-second time scales within the three-dimensional structure of enzymes may be one of the keys to explaining protein function. Professor Nicolas Doucet's team ...

NMR 'fingerprinting' for monoclonal antibodies

National Institute of Standards and Technology researchers at the Institute for Bioscience and Biotechnology Research have demonstrated the most precise method yet to measure the structural configuration of monoclonal antibodies ...

Desmoplakin's tail gets the message

Cells control the adhesion protein desmoplakin by modifying the tail end of the protein, and this process goes awry in some patients with arrhythmogenic cardiomyopathy, according to a study in The Journal of Cell Biology.

Discovery links shift in metabolism to stem cell renewal

Stem cells in early embryos have unlimited potential; they can become any type of cell, and researchers hope to one day harness this rejuvenating power to heal disease and injury. To do so, they must, among other things, ...

Siberian hamsters show what helps make seasonal clocks tick

Many animals, including humans, have internal clocks and calendars to help them regulate behavior, physiological functions and biological processes. Although scientists have extensively studied the timekeeping mechanisms ...

Flavonoids: Little changes—large effects

(Phys.org) —Scientists at the University of York have discovered that very small chemical changes to dietary flavonoids cause very large effects when the plant natural products are tested for their impact on the human immune ...

Microelectronics: Automating cancer detection

Microelectronic engineers in Singapore have developed and tested sensor technology that can detect and measure a chemical signature of bladder cancer. The light-based sensor could eventually be used for the early diagnosis ...

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