Pinpoint creation of chirality by organic catalysts

Researchers at Nagoya University have reported in Nature Communications on the development of an organic catalyst (organocatalyst) that triggers a highly stereoselective 1,6-addition of azlactones (nucleophile) to a δ-aryl ...

What happens in the cell nucleus after fertilization

A team of scientists at the Helmholtz Zentrum München shows changes in the immediate environment of DNA after the ovum and sperm fuse to form the zygote. The results suggest why all conceivable somatic cells can develop ...

Epigenetic repression suppresses genomic instability

Susan Gasser and her group at the FMI have found the pathway through which eukaryotic organisms protect their genomes from rearrangements and deletions that arise from repetitive DNA. Human genomes, like those of simple animals ...

Tags on RNA silence X chromosome in females

The addition of a chemical tag on an RNA molecule is the critical switch that inactivates one X chromosome in every cell, ensuring healthy development in all female mammals, according to new research by Weill Cornell Medicine ...

DNA molecules directly interact with each other based on sequence

Proteins play a large role in DNA regulation, but a new study finds that DNA molecules directly interact with one another in a way that's dependent on the sequence of the DNA and epigenetic factors. This could have implications ...

New insights into cooperativity in gene regulation

In a study published in Nature, Dirk Schübeler and his group at the Friedrich Miescher Institute for Biomedical Research (FMI) describe how the interplay between transcription factors and epigenetic modifications of DNA ...

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