A histone modification essential for tissue integrity

Chemical modifications of histones, the small proteins around which DNA is wrapped, are known to affect gene expression. In a study conducted in C. elegans, researchers from the Gasser group show that the defining modification ...

How to turn specific genes on and off

All the cells in an individual's body bear the same genetic code. It is the reading and writing of this code—the "turning on" and "turning off" of specific genes in specific cells—that gives the cells their identities. ...

New chemistry makes 'magic' drug improvements easier

In the last decade, scientists discovered a quirk of drug chemistry: If you add on a simple one-carbon building block to a drug, it can make the drug more potent, less toxic, or more stable.

DNA methylation regulator QSER1 identified

A team of researchers from a number of institutions in the U.S. has identified a DNA methylation regulator called QSER1. In their paper published in the journal Science, the group describes studying the valleys of unmethylated ...

The epigenetics of life at 12,000 feet

Humans inhabit an incredible range of environments across the globe, from arid deserts to frozen tundra, tropical rainforests, and some of the highest peaks on Earth. Indigenous populations that have lived in these extreme ...

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