New chemistry makes 'magic' drug improvements easier

In the last decade, scientists discovered a quirk of drug chemistry: If you add on a simple one-carbon building block to a drug, it can make the drug more potent, less toxic, or more stable.

DNA methylation regulator QSER1 identified

A team of researchers from a number of institutions in the U.S. has identified a DNA methylation regulator called QSER1. In their paper published in the journal Science, the group describes studying the valleys of unmethylated ...

The epigenetics of life at 12,000 feet

Humans inhabit an incredible range of environments across the globe, from arid deserts to frozen tundra, tropical rainforests, and some of the highest peaks on Earth. Indigenous populations that have lived in these extreme ...

Synthesis of potent antibiotic follows unusual chemical pathway

Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic's synthesis. The improved understanding of the chemistry behind this process, detailed in a new study led by Penn ...

Chronic stress causes genetic changes in chickens

How can stress in animals be measured? Scientists from Uppsala University and elsewhere have now found that what are known as epigenetic biomarkers could be used to detect long-term exposure to stress in commercially raised ...

A new RNA catalyst from the lab

Enzymes enable biochemical reactions that would otherwise not take place on their own. In nature, it is mostly proteins that function as enzymes. However, other molecules can also perform enzymatic reactions—for example ...

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