Macrophages are key cells of our innate immune response. By populating almost all tissues in our body, these cells have an essential role in maintaining our organs in a healthy state, as they constantly remove dying cells ...
Cell & Microbiology
Jul 21, 2022
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(Phys.org)—Every organ strikes its own balance between self-renewal and differentiation. At one extreme is the brain, where only a few isolated outposts are known to contribute to a largely quiescent population. At another ...
The body's immune system exists to identify and destroy foreign objects, whether they are bacteria, viruses, flecks of dirt or splinters. Unfortunately, nanoparticles designed to deliver drugs, and implanted devices like ...
Bio & Medicine
Feb 21, 2013
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The theory that pigeons' famous skill at navigation is down to iron-rich nerve cells in their beaks has been disproved by a new study published in Nature.
Plants & Animals
Apr 11, 2012
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For decades, microbiologists assumed that macrophages, immune cells that can engulf and poison bacteria and other pathogens, killed microbes by damaging their DNA. A new study from the University of Illinois disproves that.
Cell & Microbiology
Apr 27, 2009
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Salmonella is notorious for surviving and replicating in macrophages, which are normally lethal to invading bacteria because of their inhospitable environment. In a new study, researchers have discovered how a system of proteins, ...
Cell & Microbiology
Jan 11, 2024
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21
Macrophages are cells vital to the immune system and could possibly inform cell-based therapies for a variety of medical conditions. However, realizing the full potential of macrophage therapies relies on being able to see ...
Bio & Medicine
Sep 21, 2023
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"Let him who desires peace, prepare for war," wrote the Roman author Vegetius in the 4th century CE. Our bodies, it seems, live by this dictum: Even in times of peace, some cells express high levels of defensive, antiviral ...
Cell & Microbiology
Jun 28, 2023
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10
M1 and M2 are activated macrophages that protect our immune system and maintain homeostasis. Interestingly, they are characterized by distinct and opposing phenotypes. M1 macrophages are known for their bactericidal and tumoricidal ...
Biochemistry
Mar 28, 2023
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52
Using live imaging and cellular barcoding, researchers in the Stem Cell Program at Boston Children's Hospital have glimpsed how new stem cells—in this case, blood stem cells—are vetted for quality soon after they're born. ...
Molecular & Computational biology
Sep 28, 2022
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Macrophages (Greek: big eaters, from makros "large" + phagein "eat"; abbr. MΦ) are white blood cells within tissues, produced by the division of monocytes. Human macrophages are about 21 micrometres in diameter. Monocytes and macrophages are phagocytes, acting in both non-specific defense (or innate immunity) as well as to help initiate specific defense mechanisms (or adaptive immunity) of vertebrate animals. Their role is to phagocytose (engulf and then digest) cellular debris and pathogens either as stationary or as mobile cells, and to stimulate lymphocytes and other immune cells to respond to the pathogen. They can be identified by specific expression of a number of proteins including CD14, CD11b, F4/80 (mice)/EMR1 (human), Lysozyme M, MAC-1/MAC-3 and CD68 by flow cytometry or immunohistochemical staining. They move by action of Amoeboid movement.
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