Related topics: cells · organic molecules

Synthetic compound provides fast screening for potential drugs

A simple assay may benefit drug discovery for treating diabetes, Parkinson's, and Alzheimers disease, as well as studies of functional food and endocrine disruptor report researchers at Okayama University in the Journal of ...

Researchers find new signaling systems in human cells

One-third of all approved drugs target the same family of receptors: the G-protein-coupled receptors (GPCRs). Now, researchers from the University of Copenhagen, along with two American labs, have expanded the known network ...

Thermal management of hybrid nanoparticles

In a recent study published in Nanoscale, researchers show increases in cooling time for poorer hydrocarbon solvents compared to better solvents, indicate penetration of solvent into the ligand layer facilitates improved ...

Chemists synthesize a new hybrid organic-inorganic catalyst

RUDN chemists have synthesized metal complexes on the basis of the organoelemental substance silsesquioxane that consists of an organic and an inorganic part. Such hybrid systems may be used as efficient catalysts, for example, ...

Chemist develops a new catalyst for oxidation and amidation

A RUDN chemist has obtained a compound with a new structural type containing atoms of metals (copper and sodium) in a carcass structure and that is shaped like a bicycle helmet. The compound shows catalytic activity in two ...

Researchers develop a cheap, targeted antibacterial compound

An international scientific group including a RUDN chemist have developed a complex copper-based compound with stronger antibacterial properties compared to analogs, and is cheaper to produce. The scientists confirmed that ...

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Ligand

In coordination chemistry, a ligand is an ion or molecule (see also: functional group) that binds to a central metal atom to form a coordination complex. The bonding between metal and ligand generally involves formal donation of one or more of the ligand's electron pairs. The nature of metal-ligand bonding can range from covalent to ionic. Furthermore, the metal-ligand bond order can range from one to three. Ligands are viewed as Lewis bases, although rare cases are known involving Lewis acidic "ligands."

Metal and metalloids are bound to ligands in virtually all circumstances, although gaseous "naked" metal ions can be generated in high vacuum. Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox. Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry, homogeneous catalysis, and environmental chemistry.

Ligands are classified in many ways: their charge, their size (bulk), the identity of the coordinating atom(s), and the number of electrons donated to the metal (denticity or hapticity). The size of a ligand is indicated by its cone angle.

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