Related topics: cells · mouse model · virus · genes · cancer cells

Antibiotic resistance just became more complex

Bacteria that are susceptible to antibiotics can survive when enough resistant cells around them are expressing an antibiotic-deactivating factor. This new take on how the microbial context can compromise antibiotic therapy ...

New understanding of CRISPR-Cas9 tool could improve gene editing

Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic ...

CRISPR opens door to new type of medicine—'genome surgery'

Within a few years, Jim Johnsen and Delaney Van Riper may be among the first to benefit from CRISPR-Cas9 gene editing, a breakthrough that has already revolutionized biology research and promises to resurrect gene therapy.

Exploring drug delivery systems for next-generation gene therapy

Katie Whitehead, assistant professor of chemical engineering at Carnegie Mellon University, recently received the Young Faculty Award (YFA) from the Defense Advanced Research Projects Agency (DARPA). The YFA is a prestigious ...

Scientists find method to boost CRISPR efficiency

Scientists have developed a method to boost the efficiency of CRISPR gene editing in Duchenne muscular dystrophy (DMD), according to a study that could have implications for optimizing gene therapies for other diseases.

Discovery of neutron star collision is 'breakthrough' of 2017

The world's first-ever detection of two faraway neutron stars colliding, causing a massive blast that rippled through the fabric of space and time, was judged the scientific breakthrough of 2017, the journal Science said ...

Genome damage from CRISPR/Cas9 gene editing higher than thought

Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies ...

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Gene therapy

Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, such as a hereditary disease in which a deleterious mutant allele is replaced with a functional one. Although the technology is still in its infancy, it has been used with some success. Antisense therapy is not strictly a form of gene therapy, but is a genetically-mediated therapy and is often considered together with other methods.

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